Antitumor β-Glucan from the Cultured Fruit Body of Agaricus blazei

スポンサーリンク

概要

• 論文の詳細を見る

• Agaricus blazei is a medically important mushroom widely eaten and prescribed in Japan. Polysaccharide fractions were prepared from cultured A.blazei by repeated extraction with hot water(AgHWE), cold NaOH(AgCA), and then hot NaOH(AgHA). By chemical, enzymic, and NMR analyses, the primary structures of AgHWE, AgCA, and AgHA were mainly composed of 1, 6-β-glucan. Among these fractions, the NaOH extracts showed antitumor activity against the solid form of Sarcoma 180 in ICR mice. To demonstrate the active component in these fractions, several chemical and enzymic treatments were applied. These fractions were found to be i)neutral β-glucan passing DEAE-Sephadex A-25, ii)resistant to periodate oxidation(I/B)and subsequent partial acid hydrolysis(I/B/H), iii)resistant to a 1, 3-β-glucanase, zymolyase, before I/B, but sensitive after I/B/H. In addition, after I/B/H treatment of the neutral fraction of AgCAE, a signal around 86 ppm attributable to 1, 3-β-glucosidic linkage was detectable in the ^<13>C-NMR spectrum. These facts strongly suggest that a highly branched 1, 3-β-glucan segment forms the active center of the antitumor activity.

• 社団法人日本薬学会の論文
• 2001-07-01

著者

• ADACHI Yoshiyuki

  Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• OHNO Naohito

  Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• Ohno Naohito

  東京薬科大学 免疫学

• Ohno Naohito

  東京薬科大学 薬 微生物

• Ohno Naohito

  Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif

• Ohno N

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Miura N

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Nagi Miura

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Adachi Yoshiyuki

  東京薬科大学 免疫学

• Adachi Y

  Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn

• Adachi Yoshiyuki

  Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• MIURA Noriko

  Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• YADOMAE Toshiro

  Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• FURUKAWA Mai

  Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• MOTOI Masuro

  Toei Pharmaceutical Co., Ltd.

• Adachi Yoshiyuki

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Ohno Naohito

  Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc

• Miura Noriko

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Furukawa Mai

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Motoi Masuro

  Toei Pharmaceutical Co. Ltd.

• Yadomae T

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

関連論文

• An Unambiguous Assignment and Structural Analysis Using Solution NMR Experiments of O-Antigen from Escherichia coli ATCC23505 (Serotype O9)
• CAWS血管炎惹起の分子メカニズム
• Relationship between the Tissue Distribution and Antitumor Activity of Highly Branched (1→3)-β-D-Glucan, SSG
• Comparison of the Blood Clearance of Triple- and Single-Helical Schizophyllan in Mice
• Enhancement of LPS Triggered TNF-α (Tumor Necrosis Factor-α) Production by (1→3)-β-D-Glucans in Mice
• Enhancement of Cytokine Production by Macrophages Stimulated with (1→3)-β-D-Glucan, Grifolan (GRN), Isolated from Grifola frondosa
• Preparation and Antigen Specificity of an Anti-(1→3)-β-D-glucan Antibody
• Analysis of Cytokine mRNAs Induced by the Administration of a Highly Branched (1→3)-β-D-Glucan, OL-2
• Expression of Interleukin 1 Family mRNAs by a Highly Branched (1→3)-β-D-Glucan, OL-2
• Application of Limulus Test (G Pathway) for the Detection of Different Conformers of (1→3)-β-D-Glucans
• Inhibitory Effect of β-Glucans on Zymosan-Mediated Hydrogen Peroxide Production by Murine Peritoneal Macrophages in Vitro
• Immunopharmacological Characterization of a Highly Branched Fungal (1→3)-β-D-Glucan, OL-2,Isolated from Omphalia lapidescens
• Binding of Lysozyme to Synthetic Monosaccharide Lipid A Analogue, GLA60
• Limitation of Polymyxin B on Suppression of Endotoxin Shock Induced by Salmonella Infection in Mice(Miscellaneous)
• Serum Components Induce β-D-Glucan-Inhibitable Uptake of Zymosan Particles by Murine Peritoneal Macrophages
• Macrophage Activation in Vitro by Chemically Cross-Linked (1→3)-β-D-Glucans
• Change of Biological Activities of (1→3)-β-D-Glucan from Grifola frondosa upon Molecular Weight Reduction by Heat Treatment
• Involvement of Platelet Activating Factor, Histamine and Serotonin in Acute Lethal Shock Induced by Candida albicans Water-Soluble Extracellular Polysaccharide Fraction (CAWS) in Mice(Miscellaneous)
• Beta-Mannosyl Linkages Negatively Regulate Anaphylaxis and Vasculitis in Mice, Induced by CAWS, Fungal PAMPs Composed of Mannoprotein-Beta-Glucan Complex Secreted by Candida albicans(Highlighted paper selected by Editor-in-chief,Microbiology)
• Candida albicans Derived Fungal PAMPS, CAWS, Water Soluble Mannoprotein-β-Glucan Complex Shows Similar Immunotoxicological Activity with Bacterial Endotoxin from Escherichia coli O9(Microbiology)
• Dissociation of Toll-Like Receptor 2-Mediated Innate Immune Response to Zymosan by Organic Solvent-Treatment without Loss of Dectin-1 Reactivity(Molecular and Cell Biology)
• Lincomycin Protects Mice from Septic Shock in β-Glucan-Indomethacin Model(Microbiology)
• Antibiotics Protect against Septic Shock in Mice Administered β-Glucan and Indomethacin
• Cell Wall β-Glucan Derived from Candida albicans Acts as a Trigger for Autoimmune Arthritis in SKG Mice(Miscellaneous)
• Mechanism of Enhanced Hematopoietic Response by Soluble β-Glucan SCG in Cyclophosphamide-Treated Mice
• β-Glucan Derived from Zymosan Acts as an Adjuvant for Collagen-Induced Arthritis
• F1 Hybrid Mice (BALB/c×DBA/1) Are Resistant to Collagen-Induced Arthritis with β-Glucan as an Adjuvant(Miscellaneou)
• Increment of Plasma Soluble CD14 Level in Carrageenan-Primed Endotoxin Shock Model Mice(Miscellaneous)
• Effect of Nitric Oxide on β-Glucan/Indomethacin-Induced Septic Shock(Biopharmacy)
• Anti-fungal Activity of Sulfamethoxazole toward Aspergillus Species(Analytical Biochemistry)
• Antibody to Soluble 1,3/1,6-β-D-Glucan, SCG in Sera of Naive DBA/2 Mice(Miscellaneous)
• Structure and Biological Activities of β-Glucans from Yeast and Mycelial Forms of Candida albicans
• Effect of CAWS, a Mannoprotein-β-glucan Complex of Candida albicans, on Leukocyte, Endothelial Cell, and Platelet Functions in Vitro
• Systemic Inflammatory Response Associated with Augmentation and Activation of Leukocytes in Candida / Indomethacin Administered Mice
• Relationship between Solubility of Grifolan, a Fungal 1, 3-β-D-Glucan, and Production of Tumor Necrosis Factor by Macrophages in Vitro(Food & Nutrition Science)
• Antitumor β-Glucan from the Cultured Fruit Body of Agaricus blazei
• Antitumor 1,3-β-Glucan from Cultured Fruit Body of Sparassis crispa
• Sulubilized Cell Wall β-Glucan, CSBG, Is an Epitope of Candida Immune Mice
• Failure in Antitumor Activity by Overdose of an Immunomodulating β-Glucan Preparation, Sonifilan
• Characterization of Sodium Hypochlorite Degradation of β-Glucan in Relation to Its Metabolism in Vivo
• Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan from Aureobasidium pullulans to Antibodies in Human Sera
• Increase of Hematopoietic Responses by Triple or Single Helical Conformer of an Antitumor (1→3)-β-D-Glucan Preparation, Sonifilan, in Cyclophosphamide-induced Leukopenic Mice
• Increases in Hematopoietic Responses Caused by β-Glucans in Mice
• Metabolic ^C-Labeling of An Antitumor (1→3)-β-D-Glucan, SSG, from Sclerotinia sclerotiorum IFO 9395
• INDUCTION OF ALKALINE PHOSPHATASE ACTIVITY IN MURINE SPLEEN CELLS TREATED WITH VARIOUS MITOGENS
• Blocking Effect of Anti-Dectin-1 Antibodies on the Anti-tumor Activity of 1,3-β-Glucan and the Binding of Dectin-1 to 1,3-β-Glucan(Molecular and Cell Biology)
• Soy Isoflavone Aglycone Modulates A Hematopoietic Response in Combination with Soluble β-Glucan : SCG(Miscellaneous)
• Synergistic Action of β-Glucan and Platelets on Interleukin-8 Production by Human Peripheral Blood Leukocytes
• Effect of SCG, 1,3-β-D-Glucan from Sparassis crispa on the Hematopoietic Response in Cyclophosphamide Induced Leukopenic Mice
• Th1/Th2-Balancing Immunomodulating Activity of Gel-Forming(1→3)-β-Glucans from Fungi
• Adjuvant Effect of Grifolan on Antibody Production in Mice
• Activation of Murine Kupffer Cells by Administration with Gel-Forming (1→3)-β-D-Glucan from Grifola frondosa
• Nitric Oxide Synthesis in Murine Peritoneal Macrophages by Fungal β-Glucans
• Tissue Distribution of Intraperitoneally Administered (1→3)-β-D-Glucan (SSG), a Highly Branched Antitumor Glucan, in Mice
• ANTITUMOR ACTIVITY OF A β-1,3-GLUCAN OBTAINED FROM LIQUID CULTURED MYCELIUM OF GRIFOLA FRONDOSA
• Inactivation of a Particle β-Glucan by Proteins in Plasma and Serum
• Oxidative Degradation of an Antitumor (1-3)-β-D-Glucan, Grifolan
• Modulation of Antitumor Activity of Grifolan by Subsequent Administration of (1→3)-β-D-Glucanase in Vivo
• EFFECT OF A POLYSACCHARIDE FRACTION FROM GRIFOLA FRONDOSA ON IMMUNE RESPONSE IN MICE
• ANTITUMOR ACTIVITY OF A POLYSACCHARIDE FRACTION EXTRACTED FROM CULTURED FRUITING BODIES OF GRIFOLA FRONDOSA
• Architecture of Alkaline-soluble and Bioactive Polysaccharide from the Kernels of Prunus mume SIEB. et ZUCC. Assessed by Anti P-1 Antibody
• Immunochemical Characterization of Alkaline-soluble Polysaccharide, P-1, from the Kernels of Prunus mume SIEB. et ZUCC.
• Modification of Immunostimulating Activities of Grifolan by the Treatment with (1→3)-β-D-Glucanase
• Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β-Glucan in Mice
• HOST-MEDIATED ANTITUMOR EFFECT OF GRIFOLAN NMF-5N, A POLYSACCHARIDE OBTAINED FROM GRIFOLA FRONDOSA
• ANTITUMOR EFFECT OF POLYSACCHARIDE GRIFOLAN NMF-5N ON SYNGENEIC TUMOR IN MICE
• EFFECT OF A B CELL MITOGEN EXTRACTED FROM A FUNGUS PEZIZA VESICULOSA ON ANTIBODY PRODUCTION IN MICE
• BIOCHEMICAL AND PHYSICOCHEMICAL CHARACTERIZATION OF A MITOGEN OBTAINED FROM AN ORIENTAL CRUDE DRUG, TOHKI (ANGELICA ACTILOBA KITAGAWA)
• Characterization of Type X1X Capsular Polysaccharide from Streptococcus 2D 559
• Enhancement of Autolysis of Streptococcus pneumoniae by Lysozyme
• Characterization of Solubilized Products from the Cell Wall of Streptococcus pneumoniae during Autoplast Formation
• Trafficking of QD-Conjugated MPO-ANCA in Murine Systemic Vasculitis and Glomerulonephritis Model Mice
• Dectin-1 Is Not Required for the Host Defense to Cryptococcus neoformans
• Wide Range of Molecular Weight Distribution of Mitogenic Substance(s) in the Hot Water Extract of a Chinese Herbal Medicine, Bupleurum chinense
• Analysis of Mitogenic Substances in Bupleurum chinense by ESR Spectroscopy
• Saccharomyces cerevisiae- and Candida albicans-Derived Mannan Induced Production of Tumor Necrosis Factor Alpha by Human Monocytes in a CD14- and Toll-Like Receptor 4-Dependent Manner
• Contribution of N-Linked Oligosaccharides to the Expression and Functions of β-Glucan Receptor, Dectin-1(Molecular and Cell Biology)
• Increased Inhibitory Capacity of an Anti-C5a Complementary Peptide Following Acetylation of N-terminal Alanine
• Chemistry and Bioligy of Angiitis Inducer, Candida albicans Water-Soluble Mannoprotein-β-Glucan Complex (CAWS)
• PJ-525 The Cardiac Function of CAWS-induced Aortitis in DBA/2 Mouse, As a Model of Heart Failure(Infection/Inflammation/Immunity(03)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Distribution of the Mitogenic Protein, Sclerogen, in Extracts from Sclerotinia sclerotiorum IFO 9395 Assessed by Using Immunochemical Analysis
• Use of fluorescent quantum dot bioconjugates for cellular imaging of immune cells, cell organelle labeling, and nanomedicine : surface modification regulates biological function, including cytotoxicity
• Simultaneous Multicolor Detection System of the Single-Molecular Microbial Antigen with Total Internal Reflection Fluorescence Microscopy
• (1→3)-β-D-グルカン受容体 Dectin-1 の自然免疫及び抗腫瘍免疫活性作用と真菌感染防御における役割
• Preparation and Biological Activities of Sulfated Derivatives of (1→3)-β-D-Glucans
• Effect of β-Glucans on the Nitric Oxide Synthesis by Peritoneal Macrophage in Mice
• Signal Transduction Pathway on β-Glucans-Triggered Hydrogen Peroxide Production by Murine Peritoneal Macrophages in Vitro
• Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction : an animal model of Kawasaki disease
• Soy Isoflavone Aglycone Modulates Expression of Cell Surface Antigens in Vitro and in Vivo
• Activation of the Complement System by (1→3)-β-D-Glucans Having Different Degrees of Branching and Different Ultrastructures
• Enhancement of Clot Formation of Human Plasma by β-Glucans
• Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan from Aureobasidium pullulans to Antibodies in Human Sera
• Soy Isoflavone Aglycone Modulates Expression of Cell Surface Antigens in Vitro and in Vivo
• Effect of GM-CSF on cytokine induction by soluble β-glucan SCG in vitro in β-glucan-treated mice
• Characterization of rat β-glucan receptor dectin-1
• Anti-fungal Cell Wall β-glucan Antibody in Animal Sera
• Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses
• The influence of β-glucan on the growth and cell wall architecture of Aspergillus spp.
• Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses
• Vasculitis and anaphylactoid shock in mice induced by the polysaccharide fraction secreted into culture supernatants by the fungus Candida metapsilosis

もっと見る 閉じる

スポンサーリンク