Modulation of Antitumor Activity of Grifolan by Subsequent Administration of (1→3)-β-D-Glucanase in Vivo
スポンサーリンク
概要
- 論文の詳細を見る
The initiation process of effector mechanism of the antitumor activity of (1→3)-β-D-glucans has been examined in detail by applying treatment of mice with (1→3)-β-D-glucanases, kitalase (KIT) and zymolyase (ZYM), via i.p. route after i.p. administration of (1→3)-β-D-glucans, grifolan (GRN) and CM-curdlan (CM-CUD). A significant decrease of antitumor activity caused by GRN was observed by treatment with KIT within 48 h, and that caused by GRN administered via i.v. route was also reduced by the i.v. injection of KIT, although it was less effective than i.p. treatment. Pretreatment of mice with thioglycollate reduced the period of time to abrogate antitumor activity by the sequential treatment of KIT. Similar results were also observed on ZYM treatment after i.p. treatment of CM-CUD. These facts suggest that the period of manifestation of the antitumor activity by (1→3)-β-D-glucans must be longer than a few days.
- 社団法人日本薬学会の論文
著者
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
東京薬科大学 免疫学
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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YADOMAE Toshiro
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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NONO Isao
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
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OHSAWA Masumi
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
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OIKAWA Shozo
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Nono Isao
Tokyo College Of Pharmacy:nippon Beet Sugar Mfg. Co. Ltd.
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Oikawa S
Nippon Beet Sugar Mfg. Co. Ltd. Tokyo Jpn
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Ohsawa M
Nippon Beet Sugar Mfg. Co. Ltd. Tokyo Jpn
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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