Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan from Aureobasidium pullulans to Antibodies in Human Sera

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概要

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• We recently determined the structure of a unique type of 1,3-β-D-glucan obtained from Aureobasidium pullulans (AP-FBG) and found that it reacted with the antibodies in human sera. The reactivity of AP-FBG to the antibodies was stronger than that of 1,3-β-D-glucan obtained Grifola frondosa (GRN) but weaker than that of 1,3-β-D-glucan from Candida albicans (CSBG). Here, we demonstrated that AP-FBG reacted to IgG antibodies, especially those of the subclasses IgG2, IgG1, and IgG3, in human sera. Moreover, the results of competitive enzyme-linked immunosorbent assays (ELISAs) using various glucan competitors showed that these IgGs recognized branched chains at position 6. This is the first study to report that the branched chains at position 6 of β-D-glucan strongly contribute to its recognition by antibodies in human sera. This high reactivity of AP-FBG to human IgG could be advantageous for the use of this glucan in medicine, e.g., as an immunostimulatory agent.

• 社団法人 日本農芸化学会の論文

著者

• TADA Rui

  Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• ADACHI Yoshiyuki

  Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• OHNO Naohito

  Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• ISHIBASHI Ken-ichi

  Laboratory for Nanoelectronics and Spintronics, Research Institute of Electrical Communication, Toho

• Adachi Yoshiyuki

  Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Tanioka Asuka

  Advance Materials R & D Laboratory, Life Sciences Department, ADEKA Corporation

• TSUBAKI Kazufumi

  Advance Materials R & D Laboratory, Life Sciences Department, ADEKA Corporation

• Tanioka Asuka

  Advance Materials R & D Laboratory Life Sciences Department Adeka Corporation

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