Nitric Oxide Synthesis in Murine Peritoneal Macrophages by Fungal β-Glucans
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概要
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Fungal β-glucans have abilities to induce NO (nitric oxide) synthesis by macrophages in vivo, and the intensity of NO synthesis significantly varied dependent on the structure of β-glucans. The molecular mechanism of NO synthesis by β-glucans, however, has not been clarified in detail. To determine β-glucan-mediated NO production, we used various β-glucans (SPG-OH, GRN; Grifolan, SSG, OL-2,ZYM; zymosan A and ZYC; zymocel), which could enhance NO synthesis in vivo, and stimulated peritoneal macrophages (PMs) in vitro in the presence of interferon-γ (IEN-γ). Using recombinant cytokines, a minimum concentration of the cytokines for NO induction was about 20 ng/ml in the presence of IFN-γ under the experimental conditions. Of β-glucans tested, only SPG-OH and GRN produced high concentrations of IL-6 in the culture supernatants. SSG also induced NO synthesis in vitro, but concentrations of inflammatory cytokines were low even in the presence of IFN-γ. In addition, there are some β-glucans which could induce NO synthesis in vivo but not in vitro (OL-2,ZYM, ZYC). These findings suggested that NO productivity of β-glucans in vivo is regulated by several mechanisms.
- 社団法人日本薬学会の論文
- 1997-09-15
著者
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Hashimoto T
Faculty Of Pharmaceutical Sciences Hokuriku University
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橋本 忠
北陸大・薬
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Adachi Yoshiyuki
Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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YADOMAE Toshiro
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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HASHIMOTO Tomoe
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Hashimoto T
Hokuriku Univ. Kanazawa Jpn
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Hashimoto Toshihiro
Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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