Synthesis of Thyrotropin-Releasing Hormone-Related Peptides Using N^α-tert-Bytyloxycarbonyl-ω-(N-tert-butyloxycarbonylcarbamoyl)-α-amino Acids

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概要

• 論文の詳細を見る

• Application of N^α, N^<ca>-di-tert-butyloxycarbonylhomoglutamine to synthesis of thyrotropin-releasing hormone (TRH) analogs was examined. The δ-lactam formation from homoglutaminylpeptides took place more easily than γ-lactam formation from glutaminylpeptides in water or dioxane containing acetic acid. [pHgu^1,Nva^2]-TRH had dose-dependent antagonistic activity against pentobarbital anesthesia in mice, but almost no binding activity to TRH receptor in rat brain.

• 社団法人日本薬学会の論文
• 1989-11-25

著者

• 岡部 敬

  Department Of Pediatrics Kanazawa University

• 佐倉 直樹

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 広瀬 恭子

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 西島 美和子

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 橋本 忠

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 宮森 千明

  Department of Pediatrics, Kanazawa University

• 佐藤 保

  Department of Pediatrics, Kanazawa University

• 橋本 忠

  北陸大・薬

• 佐倉 直樹

  北陸大・薬

• Sakura Naoki

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 宮森 千明

  Department Of Pediatrics Kanazawa University

• Hashimoto T

  Hokuriku Univ. Kanazawa Jpn

• Hashimoto Toshihiro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• 橋本 忠

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 佐藤 保

  Department Of Pediatrics Kanazawa University

• 広瀬 恭子

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 西島 美和子

  Faculty Of Pharmaceutical Sciences Hokuriku University

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