Contractile Activity of Porcine Neuromedin U-25 and Various Neuromedin U-Related Peptide Fragments on Isolated Chicken Crop Smooth Muscle
スポンサーリンク
概要
- 論文の詳細を見る
Contractile activity of porcine neuromedin U-25 (p-NMU-25) and various neuromedin U (NMU) peptide fragment amides was examined on chicken crop smooth muscle preparation. The relative activity (expressed as RA value) of p-NMU-25 to porcine neuromedin U-8 (p-NMU-8) was 5.51±0.09,and p-NMU-25 (15-25) was the most potent fragment with an RA value of 7.78±0.05. All C-terminal 11-peptide amides of rat, rabbit and frog NMU peptides retained activity about three-fold higher than the corresponding C-terminal 8-peptide amides. The peptide segment Asn^<15>-Arg-Arg^<17> of p-NMU-25,as well as the corresponding positions of various NMU peptides : Ser^<13>-Gly-Gly^<15> of rat NMU and Ser^<15>-Arg-Gly^<17> of rabbit and frog NMUs, appeared to be involved in the structural requirements for increased contractile activity in the assay system.
- 社団法人日本薬学会の論文
- 1992-06-25
著者
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佐倉 直樹
Faculty of Pharmaceutical Sciences, Hokuriku University
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橋本 忠
Faculty of Pharmaceutical Sciences, Hokuriku University
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橋本 忠
北陸大・薬
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Kanazawa Kazushi
Faculty Of Pharmaceutical Sciences Hokuriku University
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Kurosawa K
Faculty Of Pharmaceutical Sciences Hokuriku University
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黒沢 克郎
Faculty Of Pharmaceutical Sciences Hokuriku University
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興村 桂子
Faculty Of Pharmaceutical Sciences Hokuriku University
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佐倉 直樹
北陸大・薬
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Sakura N
Hokuriku Univ. Kanazawa Jpn
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Sakura Naoki
Faculty Of Pharmaceutical Sciences Hokuriku University
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黒澤 克郎
Faculty of Pharmaceutical Sciences, Hokuriku University
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太田 聡
Faculty of Pharmaceutical Sciences, Hokuriku University
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太田 聡
Faculty Of Pharmaceutical Sciences Hokuriku University
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黒澤 克郎
Faculty Of Pharmaceutical Sciences Hokuriku University
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Hashimoto T
Hokuriku Univ. Kanazawa Jpn
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Hashimoto Toshihiro
Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.
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橋本 忠
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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