Biotransformation of hinesol Isolated from the Crude Drug Atractylodes Iancea by Aspergillus niger and Aspergillus cellulosae

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概要

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• Biotransformation of the sesquiterpene alcohol hinesol (1) with spasmolytic activity, which was prepared from the rhizome of Atractylodes lancea, was carried out by Aspergillus niger and Aspergillus cellulosae IFO 4040. Compound 1 was easily converted to compounds 2-9 by A. niger, and compounds 10 and 11 by A. cellulosae, respectively. Their stereostructures were established by a combination of high -resolution NMR spectral analysis, X-ray crystallographic analysis, and chemical reactions such as epoxydation.

• 公益社団法人日本薬学会の論文
• 1999-05-15

著者

• 田中 正一

  Graduate School Of Pharmaceutical Sciences Kyushu University

• 高岡 茂

  徳島文理大薬

• Hashimoto T

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 橋本 忠

  北陸大・薬

• HASHIMOTO Toshihiro

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• ASAKAWA Yoshinori

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Asakawa Y

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• TANAKA Masami

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• TAKAOKA Shigeru

  Faculty of Pharmaceutical Sciendes, Tokushima Bunri University

• NOMA Yoshiaki

  Faculty of Domestic Sciences, Tokushima Bunri University

• 田原 茂延

  徳島文理大学薬

• Hashimoto T

  Hokuriku Univ. Kanazawa Jpn

• 田原 茂延

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• KATO Sumie

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Noma Y

  Faculty Of Human Life Sciences Tokushima Bunri University

• Noma Yoshiaki

  Faculty Of Domestic Sciences Tokushima Bunri University

• Kato Sumie

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Asakawa Y

  Tokushima Bunri Univ. Tokushima Jpn

• Asakawa Yoshinori

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Takaoka Shigeru

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Tanaka Masami

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

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