[1-^<11>C]Octanoate as a PET Tracer for Studying Ischemic Stroke : Evaluation in a Canine Model of Thromboembolic Stroke with Positron Emission Tomography

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概要

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• Octanoate is taken up by the brain and converted in astrocytes to glutamine through the TCA cycle after β-oxidation. Consequently, [1^<11>C]octanoate might serve as a useful positron emission tomography (PET) probe for studying cerebral oxidative metabolism and/or astroglial functions. The present study attempted to evaluate the utility of using [1^<11>C]octanoate as a PET tracer for imaging and evaluating the pathopysiology of ischemic stroke. We used a canine model of thromboembolic stroke. Five male beagle dogs were implanted with an indwelling catheter in the left internal carotid artery. A single autologous blood clot was injected into the left internal carotid artery through the catheter. The brain distribution of [1^<11>C]octanoate and cerebral blood flow (CBF) were determined 24 h after insult using a high resolution PET scanner. Post mortem brain regions unstained with 2,3,5-triphenyltetrazolium chloride (TTC) were defined as infarcts. In the region of an infarct, accumulation of [1^<11>C]octanoate decreased concurrently with CBF reduction. In contrast, normal accumulation of [1^<11>C]octanoate was observed in ischemic but vital regions, suggesting that an increased accumulation of [1^<11>C]octanoate relative to CBF takes place in these regions. In conclusion, [1^<11>C]octanoate accumulated in ischemic but vital retions, indicating that [1^<11>C]octanoate is potentially useful PET tracer for imaging and evaluating the pathophysiology of ischemic stroke.

• 公益社団法人日本薬学会の論文
• 2000-08-01

著者

• Hashimoto T

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 橋本 忠

  北陸大・薬

• YAMAGUCHI Takenori

  Cerebrovascular Division, Department of Medicine, National Cardiovascular Center, Kawasaki Medical S

• Minematsu Kazuo

  Cerebrovascular Division Department Of Medicine National Cardiovascular Center

• Minematsu Kazuo

  Infomatics Science Nara Institute Of Science And Technology

• Minematsu Kazuo

  Cerebrovascular Division Department Of Internal Medicine National Cardiovascular Center

• KAWASHIMA Hisanori

  Department of Clinical Pharmacy, Oita Medical University

• 三宅 陽子

  Faculty Of Pharmaceutical Sciences Okayama University

• Tamaki Nagara

  Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic

• Hasegawa Yoko

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• HASEGAWA Yasuhiro

  Cerebrovascular Division, National Cardiovascular Center

• KUGE Yuji

  Institute for Biofunctional Research Co., Inc.,

• KAWASHIMA Hidefumi

  Institute for Biofunctional Research Co., Inc.,

• MIYAKE Yoshihiro

  Institute for Biofunctional Research Co., Inc.,

• HASHIMOTO Tadatoshi

  Takeda Chemical Industries Co., Inc.,

• IMANISHI Mitsuaki

  Takeda Chemical Industries Co., Inc.,

• SHIOMI Mie

  Takeda Chemical Industries Co., Inc.,

• HASHIMOTO Naoto

  Institute for Biofunctional Research Co., Inc.,

• Miyake Yoshihiro

  Institute For Bioftinctional Research Co. Ltd.

• Koga Masatoshi

  Cerebrovascular Division Department Of Medicine National Cardiovascular Center

• Hasegawa Yasuhiro

  Department Of Neurology St Marianna University School Of Medicine

• Yamaguchi T

  Department Of Biological Science Teikyo University Of Science And Technology

• Yamaguchi Takenori

  Cerebrovascular Division Department Of Internal Medicine National Cardiovascular Center

• Hashimoto T

  Hokuriku Univ. Kanazawa Jpn

• Kawashima H

  Institute For Health Care Science Research Center Suntory Ltd.

• Kuge Yuji

  Department Of Tracer Kinetics Hokkaido University School Of Medicine

• Kuge Yuji

  Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi

• Shiomi Mie

  Takeda Chemical Industries Co. Ltd.

• Miyake Yoko

  Faculty Of Pharmaceutical Sciences Okayama University

• Miyake Y

  Institute For Bioftinctional Research Co. Ltd.

• Tamaki Nagara

  Hokkaido Univ. Hokkaido Jpn

• Hashimoto Toshihiro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Imanishi Mitsuaki

  Takeda Chemical Industries Co. Ltd.

• Hashimoto N

  Institute For Bioftinctional Research Co. Ltd.

• Hashimoto Naoto

  Institute For Biofunctional Research C/o National Cardiovascular Center

• Hasegawa Yasuhiro

  Cerebrovascular Division National Cardiovascular Center

• Kuge Yuji

  Central Institute Of Isotope Science Hokkaido University

• Tamaki Nagara

  Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic

• HASHIMOTO Naoto

  Institute for Bioftinctional Research Co., Ltd.

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