Isolation and Structures of New Cyclomyltaylane and ent-Chamigrane-Type Sesquiterpenoids from the Liverwort Reboulia hemishaerica and Their Biotransformation by the Fungus Aspergillus niger

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概要

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• Reboulia hemisphaerica, the thalloid liverwort, contained four new cyclomyltaylane- and two new ent-β-chamigrane-type sesquiterpenoids of which the absolute stereostructures were established by a combination of two-dimensional NMR spectroscopy, X-ray crystallographic analysis, and the modified Mosher's method. Cyclomyltaylan-5α-ol and ent-β-chamigren-1α-ol were biotransformed by the fungus Aspergillus niger to afford new oxygenated matabolites. Their structures were also elucidated in the same manner as described above.

• 公益社団法人日本薬学会の論文
• 2006-07-01

著者

• Hashimoto T

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 橋本 忠

  北陸大・薬

• 橋本 忠

  北陸大学薬学部

• HASHIMOTO Toshihiro

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• ASAKAWA Yoshinori

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Asakawa Y

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• NOMA Yoshiaki

  Faculty of Domestic Sciences, Tokushima Bunri University

• Hashimoto Tadashi

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Hashimoto T

  Hokuriku Univ. Kanazawa Jpn

• Noma Y

  Faculty Of Human Life Sciences Tokushima Bunri University

• Noma Yoshiaki

  Faculty Of Domestic Sciences Tokushima Bunri University

• Asakawa Y

  Tokushima Bunri Univ. Tokushima Jpn

• Asakawa Yoshinori

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• FURUSAWA Mai

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Hashimoto Tadashi

  Drug Metabolism Laboratories Drug Development Division Yamanouchi Pharmaceutical Co. Ltd.

• Furusawa Mai

  Faculty Of Pharmaceutical Science Tokushima Bunri University

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