Characterization of Sodium Hypochlorite Degradation of β-Glucan in Relation to Its Metabolism in Vivo
スポンサーリンク
概要
- 論文の詳細を見る
Soluble (SSG, β-1,3-D-glucan obtained from the culture filtrates of a fungus, Sclerotinia sclerotiorum IFO 9395) and particulate (zymosan) β-glucans were oxidized by sodium hypochlorite (NaClO), and the oxidized products were analyzed by gel filtration and ion-exchange chromatographies and by limulus G-test to study the metabolism of β-glucans in vivo. By oxidative degradation, SSG was gradually oxidized to anionic polymers, which decreased the molecular weight and reduced the content of the sidechain at the same time. Zymosan, a particle from fungi cell wall, was easily solubilized to a high molecular weight polysaccharide by oxidative degradation. The elution profiles on ion exchange columns and the limulus G-test reactivity of the products were similar to those of polysaccharides obtained by in vivo experiments using SSG and zymosan. These results suggest that oxidative degradation is the main metabolic pathway of β-glucans in vivo, and that the sidechains would be oxidized faster than the main chain.
- 社団法人日本薬学会の論文
- 1996-11-15
著者
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Manabe Noriyoshi
International Clinical Research Center Research Institute International Medical Center Of Japan
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ADACHI Yoshiyuki
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miura N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Nagi Miura
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Adachi Yoshiyuki
Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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MIURA Noriko
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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YADOMAE Toshiro
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Miura Noriko
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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