Enhancement of Clot Formation of Human Plasma by β-Glucans
スポンサーリンク
概要
- 論文の詳細を見る
Effects of (1→3)-β-D-glucans on clot formation of human plasma were examined. Gel forming 6 branched (1→3)-β-D-glucans, SSG, branched at every other main chain glucosyl unit, grifolan (GRN) and schizophyllan, branched at one third of main chain glucosyl unit, enhanced clot formation of human plasma. GRN derivatives also increased the contents of clot, but less effectively than GRN. This effect was dependent on dose, molecular weight (>20K), side chain (branching), and ultrastructure (single chain conformer) of the β-glucans. It may be important for the mechanism of (1→3)-β-D-glucan induced enhancement of plasma clotting to activate factor XII, to bind with fibrinogen, and to increase the local concentration of the clotting system by steric exclusion.
- 公益社団法人日本薬学会の論文
著者
-
SAITO Kazuo
The Tokyo Metropolitan Research Laboratory of Public Health
-
OHNO NAOHITO
Tokyo College of Pharmacy
-
Ohno Naohito
東京薬科大学 免疫学
-
Ohno Naohito
東京薬科大学 薬 微生物
-
Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
-
YADOMAE Toshiro
Tokyo University of Pharmacy and Life Science, School of Pharmacy
-
Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
-
Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
-
Suzuki T
Josai Univ. Saitama Jpn
-
SUZUKI Tatsuya
Tokyo College of Pharmacy
-
SAITO Kazuo
Tokyo College of Pharmacy
-
Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
-
Yadomae Toshiro
Tokyo College Of Pharmacy
-
Saito K
The Tokyo Metropolitan Research Laboratory Of Public Health
-
Suzuki Tatsuya
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science:Laboratory of Microbiology, Hatano Research Institute, Food and Drug Safety Center
関連論文
- An Unambiguous Assignment and Structural Analysis Using Solution NMR Experiments of O-Antigen from Escherichia coli ATCC23505 (Serotype O9)
- 液体クロマトグラフィー/大気圧化学イオン化-質量分析法による食品中のアスパルテーム及びジケトピペラジンの分析
- Conformational Changes of the Two Different Conformers of Grifolan in Sodium Hydroxide, Urea or Dimethylsulfoxide Solution(Biological)
- Involvement of Platelet Activating Factor, Histamine and Serotonin in Acute Lethal Shock Induced by Candida albicans Water-Soluble Extracellular Polysaccharide Fraction (CAWS) in Mice(Miscellaneous)
- Beta-Mannosyl Linkages Negatively Regulate Anaphylaxis and Vasculitis in Mice, Induced by CAWS, Fungal PAMPs Composed of Mannoprotein-Beta-Glucan Complex Secreted by Candida albicans(Highlighted paper selected by Editor-in-chief,Microbiology)
- Candida albicans Derived Fungal PAMPS, CAWS, Water Soluble Mannoprotein-β-Glucan Complex Shows Similar Immunotoxicological Activity with Bacterial Endotoxin from Escherichia coli O9(Microbiology)
- Dissociation of Toll-Like Receptor 2-Mediated Innate Immune Response to Zymosan by Organic Solvent-Treatment without Loss of Dectin-1 Reactivity(Molecular and Cell Biology)
- Lincomycin Protects Mice from Septic Shock in β-Glucan-Indomethacin Model(Microbiology)
- Antibiotics Protect against Septic Shock in Mice Administered β-Glucan and Indomethacin
- Cell Wall β-Glucan Derived from Candida albicans Acts as a Trigger for Autoimmune Arthritis in SKG Mice(Miscellaneous)
- Mechanism of Enhanced Hematopoietic Response by Soluble β-Glucan SCG in Cyclophosphamide-Treated Mice
- β-Glucan Derived from Zymosan Acts as an Adjuvant for Collagen-Induced Arthritis
- F1 Hybrid Mice (BALB/c×DBA/1) Are Resistant to Collagen-Induced Arthritis with β-Glucan as an Adjuvant(Miscellaneou)
- Increment of Plasma Soluble CD14 Level in Carrageenan-Primed Endotoxin Shock Model Mice(Miscellaneous)
- Effect of Nitric Oxide on β-Glucan/Indomethacin-Induced Septic Shock(Biopharmacy)
- Anti-fungal Activity of Sulfamethoxazole toward Aspergillus Species(Analytical Biochemistry)
- Antibody to Soluble 1,3/1,6-β-D-Glucan, SCG in Sera of Naive DBA/2 Mice(Miscellaneous)
- Structure and Biological Activities of β-Glucans from Yeast and Mycelial Forms of Candida albicans
- Effect of CAWS, a Mannoprotein-β-glucan Complex of Candida albicans, on Leukocyte, Endothelial Cell, and Platelet Functions in Vitro
- Systemic Inflammatory Response Associated with Augmentation and Activation of Leukocytes in Candida / Indomethacin Administered Mice
- Relationship between Solubility of Grifolan, a Fungal 1, 3-β-D-Glucan, and Production of Tumor Necrosis Factor by Macrophages in Vitro(Food & Nutrition Science)
- Antitumor β-Glucan from the Cultured Fruit Body of Agaricus blazei
- Antitumor 1,3-β-Glucan from Cultured Fruit Body of Sparassis crispa
- Sulubilized Cell Wall β-Glucan, CSBG, Is an Epitope of Candida Immune Mice
- Failure in Antitumor Activity by Overdose of an Immunomodulating β-Glucan Preparation, Sonifilan
- Characterization of Sodium Hypochlorite Degradation of β-Glucan in Relation to Its Metabolism in Vivo
- Increase of Hematopoietic Responses by Triple or Single Helical Conformer of an Antitumor (1→3)-β-D-Glucan Preparation, Sonifilan, in Cyclophosphamide-induced Leukopenic Mice
- Increases in Hematopoietic Responses Caused by β-Glucans in Mice
- Metabolic ^C-Labeling of An Antitumor (1→3)-β-D-Glucan, SSG, from Sclerotinia sclerotiorum IFO 9395
- INDUCTION OF ALKALINE PHOSPHATASE ACTIVITY IN MURINE SPLEEN CELLS TREATED WITH VARIOUS MITOGENS
- Blocking Effect of Anti-Dectin-1 Antibodies on the Anti-tumor Activity of 1,3-β-Glucan and the Binding of Dectin-1 to 1,3-β-Glucan(Molecular and Cell Biology)
- Soy Isoflavone Aglycone Modulates A Hematopoietic Response in Combination with Soluble β-Glucan : SCG(Miscellaneous)
- Synergistic Action of β-Glucan and Platelets on Interleukin-8 Production by Human Peripheral Blood Leukocytes
- Effect of SCG, 1,3-β-D-Glucan from Sparassis crispa on the Hematopoietic Response in Cyclophosphamide Induced Leukopenic Mice
- Th1/Th2-Balancing Immunomodulating Activity of Gel-Forming(1→3)-β-Glucans from Fungi
- Adjuvant Effect of Grifolan on Antibody Production in Mice
- Activation of Murine Kupffer Cells by Administration with Gel-Forming (1→3)-β-D-Glucan from Grifola frondosa
- Nitric Oxide Synthesis in Murine Peritoneal Macrophages by Fungal β-Glucans
- Tissue Distribution of Intraperitoneally Administered (1→3)-β-D-Glucan (SSG), a Highly Branched Antitumor Glucan, in Mice
- ANTITUMOR ACTIVITY OF A β-1,3-GLUCAN OBTAINED FROM LIQUID CULTURED MYCELIUM OF GRIFOLA FRONDOSA
- Inactivation of a Particle β-Glucan by Proteins in Plasma and Serum
- Oxidative Degradation of an Antitumor (1-3)-β-D-Glucan, Grifolan
- Modulation of Antitumor Activity of Grifolan by Subsequent Administration of (1→3)-β-D-Glucanase in Vivo
- EFFECT OF A POLYSACCHARIDE FRACTION FROM GRIFOLA FRONDOSA ON IMMUNE RESPONSE IN MICE
- ANTITUMOR ACTIVITY OF A POLYSACCHARIDE FRACTION EXTRACTED FROM CULTURED FRUITING BODIES OF GRIFOLA FRONDOSA
- Architecture of Alkaline-soluble and Bioactive Polysaccharide from the Kernels of Prunus mume SIEB. et ZUCC. Assessed by Anti P-1 Antibody
- Immunochemical Characterization of Alkaline-soluble Polysaccharide, P-1, from the Kernels of Prunus mume SIEB. et ZUCC.
- Modification of Immunostimulating Activities of Grifolan by the Treatment with (1→3)-β-D-Glucanase
- Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β-Glucan in Mice
- HOST-MEDIATED ANTITUMOR EFFECT OF GRIFOLAN NMF-5N, A POLYSACCHARIDE OBTAINED FROM GRIFOLA FRONDOSA
- ANTITUMOR EFFECT OF POLYSACCHARIDE GRIFOLAN NMF-5N ON SYNGENEIC TUMOR IN MICE
- EFFECT OF A B CELL MITOGEN EXTRACTED FROM A FUNGUS PEZIZA VESICULOSA ON ANTIBODY PRODUCTION IN MICE
- BIOCHEMICAL AND PHYSICOCHEMICAL CHARACTERIZATION OF A MITOGEN OBTAINED FROM AN ORIENTAL CRUDE DRUG, TOHKI (ANGELICA ACTILOBA KITAGAWA)
- Characterization of Type X1X Capsular Polysaccharide from Streptococcus 2D 559
- Enhancement of Autolysis of Streptococcus pneumoniae by Lysozyme
- Characterization of Solubilized Products from the Cell Wall of Streptococcus pneumoniae during Autoplast Formation
- Trafficking of QD-Conjugated MPO-ANCA in Murine Systemic Vasculitis and Glomerulonephritis Model Mice
- Dectin-1 Is Not Required for the Host Defense to Cryptococcus neoformans
- Wide Range of Molecular Weight Distribution of Mitogenic Substance(s) in the Hot Water Extract of a Chinese Herbal Medicine, Bupleurum chinense
- Analysis of Mitogenic Substances in Bupleurum chinense by ESR Spectroscopy
- Contribution of N-Linked Oligosaccharides to the Expression and Functions of β-Glucan Receptor, Dectin-1(Molecular and Cell Biology)
- Distribution of the Mitogenic Protein, Sclerogen, in Extracts from Sclerotinia sclerotiorum IFO 9395 Assessed by Using Immunochemical Analysis
- Study on the Immunomodulating Activities of Hot Water Extracts of Sclerotia of Sclerotinia sclerotiorum IFO 9395 Strain Cultured on Several Media(Biological)
- ANTITUMOR ACTIVITY OF A HIGHLY BRANCHED (1→3)-β-D-GLUCAN, SSG, OBTAINED FROM SCLEROTINIA SCLEROTIORUM IFO 9395
- Preparation and Biological Activities of Sulfated Derivatives of (1→3)-β-D-Glucans
- Effect of β-Glucans on the Nitric Oxide Synthesis by Peritoneal Macrophage in Mice
- Signal Transduction Pathway on β-Glucans-Triggered Hydrogen Peroxide Production by Murine Peritoneal Macrophages in Vitro
- Interaction of Microcrystalline Cellulose and Water in Granules Prepared by a High-Shear Mixer
- Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction : an animal model of Kawasaki disease
- Activation of the Complement System by (1→3)-β-D-Glucans Having Different Degrees of Branching and Different Ultrastructures
- Enhancement of Clot Formation of Human Plasma by β-Glucans
- Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan from Aureobasidium pullulans to Antibodies in Human Sera
- Enhancement of Hematopoietic Response of Mice by Intraperitoneal Administration of a β-Glucan, SSG, Obtained from Sclerotinia sclerotiorum
- Soy Isoflavone Aglycone Modulates Expression of Cell Surface Antigens in Vitro and in Vivo
- Effect of GM-CSF on cytokine induction by soluble β-glucan SCG in vitro in β-glucan-treated mice
- Development of a Rapid Process Monitoring Method for Dry-Coated Tableting Process by Using Near-Infrared Spectroscopy
- Characterization of rat β-glucan receptor dectin-1
- The Effects of a Highly Branched β-1,3-Glucan, SSG, Obtained from Sclerotinia sclerotiorum IFO 9395 on the Growth of Syngeneic Tumors in Mice
- GC/MSによるリンゴ果汁中のパツリンの定量および確認法
- Anti-fungal Cell Wall β-glucan Antibody in Animal Sera
- The influence of β-glucan on the growth and cell wall architecture of Aspergillus spp.
- Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses