Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses

スポンサーリンク

概要

• 論文の詳細を見る

• Kjellmaniella crassifolia Miyabe (gagome) is a brown alga. Oral gagome administration (oral gagome) resulted in significant upregulation of IL-10 and IFNγ production by Peyer’s patch cells. To assess the adjuvant activity of oral gagome, treated mice were subcutaneously injected with ovalbumin (OVA). The production of cytokines from antigen (Ag)-specific T cells in draining lymph nodes (dLN) and their proliferative response were significantly increased as compared with the control group. These enhancements were associated with increased CD44hiCD62L− activated/memory T cells in dLN as well as upregulation of Ag-specific IgA level in luminal contents. No upregulation of cytokine production by dLN T cells was observed in dectin-1-deficient mice, suggesting that the effect of gagome on cytokine production is largely dependent on the dectin-1 pathway despite its composite constituents. Our findings indicate that gagome is an effective immunomodulator and a potent adjuvant for both the intestinal and the systemic immune response.

• 社団法人 日本農芸化学会の論文
• 2011-11-23

著者

• Sugi Masahito

  Hokkaido Research Institute, Nissei Bio Co., Ltd.

• OHNO Naohito

  Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• Ohno Naohito

  東京薬科大学 免疫学

• Ohno Naohito

  東京薬科大学 薬 微生物

• Ohno Naohito

  Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif

• Ohno N

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Adachi Yoshiyuki

  東京薬科大学 免疫学

• Adachi Y

  Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn

• Adachi Yoshiyuki

  Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Ohno Naohito

  Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc

• Iwakura Yoichiro

  京都府立医科大学 医学研究科微生物学教室

• Ohno Naohito

  Tokyo College Of Pharmacy:the Tokyo Metropolitan Research Laboratory Of Public Health

• Iwakura Yoichiro

  Laboratory Animal Research Center Institute Of Medical Science The University Of Tokyo

• Ohno N

  Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma

• Iwakura Yoichiro

  Center For Experimental Medicine And Systems Biology Institute Of Medical Science University Of Toky

• Adachi Yoshiyuki

  Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• YAN Huimin

  Molecular Composite Medicine Research Group, Biomedical Research Institute, National Institute of Ad

• KAKUTA Shigeru

  Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The Universi

• NISHIHARA Masao

  Hokkaido Research Institute, Nissei Bio Co., Ltd.

• TSUJI Noriko

  Molecular Composite Medicine Research Group, Biomedical Research Institute, National Institute of Ad

• Tsuji Noriko

  Molecular Composite Medicine Research Group Biomedical Research Institute National Institute Of Advanced Industrial Science And Technology (aist)

• Kakuta Shigeru

  Center For Experimental Medicine And Systems Biology The Institute Of Medical Science The University Of Tokyo

• Sugi Masahito

  Hokkaido Research Institute Nissei Bio Co. Ltd.

• Yan Huimin

  Molecular Composite Medicine Research Group Biomedical Research Institute National Institute Of Advanced Industrial Science And Technology (aist)

• Iwakura Yoichiro

  Center For Experimental Medicine And Systems Biology Inst. Of Medical Sci. The Univ. Of Tokyo

• Nishihara Masao

  Hokkaido Research Institute Nissei Bio Co. Ltd.

関連論文

• An Unambiguous Assignment and Structural Analysis Using Solution NMR Experiments of O-Antigen from Escherichia coli ATCC23505 (Serotype O9)
• Limitation of Polymyxin B on Suppression of Endotoxin Shock Induced by Salmonella Infection in Mice(Miscellaneous)
• Preferential Blockade of Dioxin-Induced Activation of the Aryl Hydrocarbon Receptor by Antrodia camphorata
• The Role of IFN-γ and Toll-Like Receptors in Nephropathy Induced by Toxoplasma gondii Infection
• Evaluation of the Effects of Sulfamethoxazole on Toxoplasma gondii Loads and Stage Conversion in IFN-γ Knockout Mice Using QC-PCR
• Pathogenicity of Toxoplasma gondii through B-2 Cell-Mediated Downregulation of Host Defense Responses
• Involvement of Platelet Activating Factor, Histamine and Serotonin in Acute Lethal Shock Induced by Candida albicans Water-Soluble Extracellular Polysaccharide Fraction (CAWS) in Mice(Miscellaneous)
• Beta-Mannosyl Linkages Negatively Regulate Anaphylaxis and Vasculitis in Mice, Induced by CAWS, Fungal PAMPs Composed of Mannoprotein-Beta-Glucan Complex Secreted by Candida albicans(Highlighted paper selected by Editor-in-chief,Microbiology)
• Candida albicans Derived Fungal PAMPS, CAWS, Water Soluble Mannoprotein-β-Glucan Complex Shows Similar Immunotoxicological Activity with Bacterial Endotoxin from Escherichia coli O9(Microbiology)
• Dissociation of Toll-Like Receptor 2-Mediated Innate Immune Response to Zymosan by Organic Solvent-Treatment without Loss of Dectin-1 Reactivity(Molecular and Cell Biology)
• Lincomycin Protects Mice from Septic Shock in β-Glucan-Indomethacin Model(Microbiology)
• Antibiotics Protect against Septic Shock in Mice Administered β-Glucan and Indomethacin
• Cell Wall β-Glucan Derived from Candida albicans Acts as a Trigger for Autoimmune Arthritis in SKG Mice(Miscellaneous)
• Mechanism of Enhanced Hematopoietic Response by Soluble β-Glucan SCG in Cyclophosphamide-Treated Mice
• β-Glucan Derived from Zymosan Acts as an Adjuvant for Collagen-Induced Arthritis
• F1 Hybrid Mice (BALB/c×DBA/1) Are Resistant to Collagen-Induced Arthritis with β-Glucan as an Adjuvant(Miscellaneou)
• Increment of Plasma Soluble CD14 Level in Carrageenan-Primed Endotoxin Shock Model Mice(Miscellaneous)
• Effect of Nitric Oxide on β-Glucan/Indomethacin-Induced Septic Shock(Biopharmacy)
• Anti-fungal Activity of Sulfamethoxazole toward Aspergillus Species(Analytical Biochemistry)
• Antibody to Soluble 1,3/1,6-β-D-Glucan, SCG in Sera of Naive DBA/2 Mice(Miscellaneous)
• Structure and Biological Activities of β-Glucans from Yeast and Mycelial Forms of Candida albicans
• Effect of CAWS, a Mannoprotein-β-glucan Complex of Candida albicans, on Leukocyte, Endothelial Cell, and Platelet Functions in Vitro
• Systemic Inflammatory Response Associated with Augmentation and Activation of Leukocytes in Candida / Indomethacin Administered Mice
• Relationship between Solubility of Grifolan, a Fungal 1, 3-β-D-Glucan, and Production of Tumor Necrosis Factor by Macrophages in Vitro(Food & Nutrition Science)
• Antitumor β-Glucan from the Cultured Fruit Body of Agaricus blazei
• Antitumor 1,3-β-Glucan from Cultured Fruit Body of Sparassis crispa
• Sulubilized Cell Wall β-Glucan, CSBG, Is an Epitope of Candida Immune Mice
• Failure in Antitumor Activity by Overdose of an Immunomodulating β-Glucan Preparation, Sonifilan
• Characterization of Sodium Hypochlorite Degradation of β-Glucan in Relation to Its Metabolism in Vivo
• Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan from Aureobasidium pullulans to Antibodies in Human Sera
• CD44 and Bak Expression in IL-6 or TNF-alpha Gene Knockout Mice After Whole Lung Irradiation
• Increase of Hematopoietic Responses by Triple or Single Helical Conformer of an Antitumor (1→3)-β-D-Glucan Preparation, Sonifilan, in Cyclophosphamide-induced Leukopenic Mice
• Increases in Hematopoietic Responses Caused by β-Glucans in Mice
• Metabolic ^C-Labeling of An Antitumor (1→3)-β-D-Glucan, SSG, from Sclerotinia sclerotiorum IFO 9395
• INDUCTION OF ALKALINE PHOSPHATASE ACTIVITY IN MURINE SPLEEN CELLS TREATED WITH VARIOUS MITOGENS
• Blocking Effect of Anti-Dectin-1 Antibodies on the Anti-tumor Activity of 1,3-β-Glucan and the Binding of Dectin-1 to 1,3-β-Glucan(Molecular and Cell Biology)
• Soy Isoflavone Aglycone Modulates A Hematopoietic Response in Combination with Soluble β-Glucan : SCG(Miscellaneous)
• Synergistic Action of β-Glucan and Platelets on Interleukin-8 Production by Human Peripheral Blood Leukocytes
• Effect of SCG, 1,3-β-D-Glucan from Sparassis crispa on the Hematopoietic Response in Cyclophosphamide Induced Leukopenic Mice
• Th1/Th2-Balancing Immunomodulating Activity of Gel-Forming(1→3)-β-Glucans from Fungi
• Adjuvant Effect of Grifolan on Antibody Production in Mice
• Activation of Murine Kupffer Cells by Administration with Gel-Forming (1→3)-β-D-Glucan from Grifola frondosa
• Nitric Oxide Synthesis in Murine Peritoneal Macrophages by Fungal β-Glucans
• Tissue Distribution of Intraperitoneally Administered (1→3)-β-D-Glucan (SSG), a Highly Branched Antitumor Glucan, in Mice
• ANTITUMOR ACTIVITY OF A β-1,3-GLUCAN OBTAINED FROM LIQUID CULTURED MYCELIUM OF GRIFOLA FRONDOSA
• Inactivation of a Particle β-Glucan by Proteins in Plasma and Serum
• Oxidative Degradation of an Antitumor (1-3)-β-D-Glucan, Grifolan
• Modulation of Antitumor Activity of Grifolan by Subsequent Administration of (1→3)-β-D-Glucanase in Vivo
• EFFECT OF A POLYSACCHARIDE FRACTION FROM GRIFOLA FRONDOSA ON IMMUNE RESPONSE IN MICE
• ANTITUMOR ACTIVITY OF A POLYSACCHARIDE FRACTION EXTRACTED FROM CULTURED FRUITING BODIES OF GRIFOLA FRONDOSA
• Interleukin-1β and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression
• Architecture of Alkaline-soluble and Bioactive Polysaccharide from the Kernels of Prunus mume SIEB. et ZUCC. Assessed by Anti P-1 Antibody
• Immunochemical Characterization of Alkaline-soluble Polysaccharide, P-1, from the Kernels of Prunus mume SIEB. et ZUCC.
• Modification of Immunostimulating Activities of Grifolan by the Treatment with (1→3)-β-D-Glucanase
• Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β-Glucan in Mice
• HOST-MEDIATED ANTITUMOR EFFECT OF GRIFOLAN NMF-5N, A POLYSACCHARIDE OBTAINED FROM GRIFOLA FRONDOSA
• ANTITUMOR EFFECT OF POLYSACCHARIDE GRIFOLAN NMF-5N ON SYNGENEIC TUMOR IN MICE
• EFFECT OF A B CELL MITOGEN EXTRACTED FROM A FUNGUS PEZIZA VESICULOSA ON ANTIBODY PRODUCTION IN MICE
• BIOCHEMICAL AND PHYSICOCHEMICAL CHARACTERIZATION OF A MITOGEN OBTAINED FROM AN ORIENTAL CRUDE DRUG, TOHKI (ANGELICA ACTILOBA KITAGAWA)
• Characterization of Type X1X Capsular Polysaccharide from Streptococcus 2D 559
• Enhancement of Autolysis of Streptococcus pneumoniae by Lysozyme
• Characterization of Solubilized Products from the Cell Wall of Streptococcus pneumoniae during Autoplast Formation
• Trafficking of QD-Conjugated MPO-ANCA in Murine Systemic Vasculitis and Glomerulonephritis Model Mice
• IL-1α, but not IL-1β, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity
• Dectin-1 Is Not Required for the Host Defense to Cryptococcus neoformans
• Involvement of IL-17 in Fas ligand-induced inflammation
• Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis
• Wide Range of Molecular Weight Distribution of Mitogenic Substance(s) in the Hot Water Extract of a Chinese Herbal Medicine, Bupleurum chinense
• Analysis of Mitogenic Substances in Bupleurum chinense by ESR Spectroscopy
• Saccharomyces cerevisiae- and Candida albicans-Derived Mannan Induced Production of Tumor Necrosis Factor Alpha by Human Monocytes in a CD14- and Toll-Like Receptor 4-Dependent Manner
• Contribution of N-Linked Oligosaccharides to the Expression and Functions of β-Glucan Receptor, Dectin-1(Molecular and Cell Biology)
• Diurnal Variation of Heart Rate, Locomotor Activity, and Body Temperature in Interleukin-1α/β Doubly Deficient Mice
• Increased Inhibitory Capacity of an Anti-C5a Complementary Peptide Following Acetylation of N-terminal Alanine
• Chemistry and Bioligy of Angiitis Inducer, Candida albicans Water-Soluble Mannoprotein-β-Glucan Complex (CAWS)
• PJ-525 The Cardiac Function of CAWS-induced Aortitis in DBA/2 Mouse, As a Model of Heart Failure(Infection/Inflammation/Immunity(03)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-363 Deficiency of Interleukin-1 Receptor Antagonist Induces Aortic Valve Stenosis in BALB/c Mice(Valvular heart disease/Pericarditis/Cardiac tumor-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Distribution of the Mitogenic Protein, Sclerogen, in Extracts from Sclerotinia sclerotiorum IFO 9395 Assessed by Using Immunochemical Analysis
• Study on the Immunomodulating Activities of Hot Water Extracts of Sclerotia of Sclerotinia sclerotiorum IFO 9395 Strain Cultured on Several Media(Biological)
• Presence of A Higher Molecular Weight β-1, 4-Galactosyltransferase in Mouse Liver
• Role of Tumor Necrosis Factor-Alpha and Interferon-Gamma in Helicobacter pylori Infection
• IL-1β, but not IL-1α, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses
• Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
• (1→3)-β-D-グルカン受容体 Dectin-1 の自然免疫及び抗腫瘍免疫活性作用と真菌感染防御における役割
• IL-4 Is Required for Defense against Mycobacterial Infection
• Preparation and Biological Activities of Sulfated Derivatives of (1→3)-β-D-Glucans
• Effect of β-Glucans on the Nitric Oxide Synthesis by Peritoneal Macrophage in Mice
• Signal Transduction Pathway on β-Glucans-Triggered Hydrogen Peroxide Production by Murine Peritoneal Macrophages in Vitro
• Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction : an animal model of Kawasaki disease
• Soy Isoflavone Aglycone Modulates Expression of Cell Surface Antigens in Vitro and in Vivo
• Activation of the Complement System by (1→3)-β-D-Glucans Having Different Degrees of Branching and Different Ultrastructures
• Enhancement of Clot Formation of Human Plasma by β-Glucans
• Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan from Aureobasidium pullulans to Antibodies in Human Sera
• Soy Isoflavone Aglycone Modulates Expression of Cell Surface Antigens in Vitro and in Vivo
• Effect of GM-CSF on cytokine induction by soluble β-glucan SCG in vitro in β-glucan-treated mice
• Characterization of rat β-glucan receptor dectin-1
• Anti-fungal Cell Wall β-glucan Antibody in Animal Sera
• Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses
• The influence of β-glucan on the growth and cell wall architecture of Aspergillus spp.
• Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses
• Vasculitis and anaphylactoid shock in mice induced by the polysaccharide fraction secreted into culture supernatants by the fungus Candida metapsilosis

もっと見る 閉じる

スポンサーリンク