Preferential Blockade of Dioxin-Induced Activation of the Aryl Hydrocarbon Receptor by Antrodia camphorata
スポンサーリンク
概要
- 論文の詳細を見る
Halogenated and polycyclic aromatic hydrocarbons are widely distributed pollutants in environments. These toxic substances activate the aryl hydrocarbon receptor (AhR) and thereby cause a broad spectrum of pathological changes. Development of AhR inhibitors will be useful for prevention of diseases caused by AhR activation. Using the dioxin responsive element (DRE)-based sensing via secreted alkaline phosphatase (DRESSA), we examined effects of Antrodia camphorata, a mycerial extract, on the activation of AhR by halogenated and polycyclic aromatic hydrocarbons. We found that Antrodia camphorata markedly suppressed activation of AhR triggered by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In contrast, activation of AhR by polycyclic aromatic hydrocarbons (benzo[a]pyrene and 3-methylcholanthrene) was inhibited only modestly by this mycelium. Similarly, Antrodia camphorata only mildly attenuated activation of AhR by cigarette smoke that contains polycyclic aromatic hydrocarbons. Consistent with these results, Northern blot analysis revealed that DRE-driven exogenous and endogenous gene expression triggered by TCDD was abolished by Antrodia camphorata, whereas it did not substantially affect DRE-induced transcription triggered by benzo[a]pyrene, 3-methylcholanthrene or cigarette smoke. We also found that the inhibitory effect of Antrodia camphorata on TCDD-induced AhR activation was ascribed to neither down-regulation of AhR, down-regulation of the AhR nuclear translocator, nor up-regulation of the AhR repressor. These results suggest that Antrodia camphorata preferentially inhibits AhR activation and DRE-dependent gene expression triggered by dioxin.
著者
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TAKAHASHI Shuhei
Department of Mechanical and Systems Engineering, Gifu University
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Mukai Mai
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
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Hayakawa Kunihiro
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
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Okamura Maro
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
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Tagawa Yasuhiro
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
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Nakajima Shotaro
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
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Saito Yukinori
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
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Yao Jian
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
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Nishimura Daisuke
Hokkaido Research Institute, Nissei Bio Co., Ltd.
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Sugi Masahito
Hokkaido Research Institute, Nissei Bio Co., Ltd.
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Matsunaga Masaji
Hokkaido Research Institute, Nissei Bio Co., Ltd.
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Kitamura Masanori
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
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Saito Yukinori
Department Of Electrical Engineering Yamanashi University
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Yao Jian
Department Of Molecular Signaling Interdisciplinary Graduate School Of Medicine And Engineering
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Takahashi Shuhei
Department Of Civil Engineering Kitami Institute Of Technology
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Kitamura Masanori
Department Of Molecular Signaling Interdisciplinary Graduate School Of Medicine And Engineering
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Sugi Masahito
Hokkaido Research Institute Nissei Bio Co. Ltd.
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YAO Jian
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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Takahashi Shuhei
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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TAKAHASHI Shuhei
Department of Applied Chemistry, School of Science and Technology, Meiji University
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