Blockade of the Aryl Hydrocarbon Receptor Pathway Triggered by Dioxin, Polycyclic Aromatic Hydrocarbons and Cigarette Smoke by Phellinus linteus(Molecular and Cell Biology)
スポンサーリンク
概要
- 論文の詳細を見る
Environmental pollutants including halogenated and polycyclic aromatic hydrocarbons activate the aryl hydrocarbon receptor (AhR) and thereby cause a wide range of pathological changes. Development of AhR antagonists will be useful for prevention and treatment of diseases related to AhR activation. Towards this end, we aimed in the present study at seeking for potential inhibitors of the AhR pathway in mycelial extracts using the dioxin responsive element-based sensing via secreted alkaline phosphatase (DRESSA). Through the screening of 13 mycelia, extracts prepared from Phellinus linteus, Cordyceps militaris and Hericium erinaceum inhibited activation of AhR by 2,3,7,8-tetrachlorodibenzo-p-dioxin, benzo[a]pyrene or 3-methylcholanthrene. Subsequent studies revealed that only Phellinus linteus suppressed activation of AhR and AhR-dependent gene expression triggered by all of these agonists. Cigarette smoke is known to contain a number of halogenated and polycyclic aromatic hydrocarbons. We found that Phellinus linteus has the potential to block activation of AhR and AhR-dependent gene expression triggered by cigarette smoke. Furthermore, the inhibitory effect of Phellinus linteus on the AhR pathway was independent of; 1) depression of AhR or AhR nuclear translocator, and 2) induction of AhR repressor. We conclude that Phellinus linteus contains potent inhibitor(s) of AhR activation and may be useful for prevention of pathologies associated with aberrant activation of AhR.
- 2008-10-01
著者
-
Mukai Mai
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
-
Hayakawa Kunihiro
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
-
Okamura Maro
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
-
Tagawa Yasuhiro
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
-
Yao Jian
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
-
Kitamura Masanori
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
-
Yao Jian
山梨大学 医学工学総合研究部分子情報伝達学
-
Yao Jian
Department Of Molecular Signaling Interdisciplinary Graduate School Of Medicine And Engineering
-
NAKAMURA Tomoyuki
Applied Fungi Institute, IBI Corporation
-
Tagawa Yasuhiro
Dep. Of Molecular Signaling Interdisciplinary Graduate School Of Medicine And Engineering Univ. Of Y
-
Kitamura Masanori
Dep. Of Molecular Signaling Interdisciplinary Graduate School Of Medicine And Engineering Univ. Of Y
-
Kitamura Masanori
Department Of Molecular Signaling Interdisciplinary Graduate School Of Medicine And Engineering
-
Nakamura Tomoyuki
Applied Fungi Institute Ibi Corporation
-
KASAI Ayumi
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
-
HIRAMATSU Nobuhiko
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, Un
-
Kasai Ayumi
Department Of Molecular Signaling Interdisciplinary Graduate School Of Medicine And Engineering Univ
-
Hiramatsu Nobuhiko
Department Of Molecular Signaling Interdisciplinary Graduate School Of Medicine And Engineering Univ
-
Okamura Maro
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
関連論文
- Preferential Blockade of Dioxin-Induced Activation of the Aryl Hydrocarbon Receptor by Antrodia camphorata
- Blockade of the Aryl Hydrocarbon Receptor Pathway Triggered by Dioxin, Polycyclic Aromatic Hydrocarbons and Cigarette Smoke by Phellinus linteus(Molecular and Cell Biology)
- Gap Junction in Glomerular Mesangial Cells
- Detection of IL-2 Receptor Gene Expression in Peripheral Blood from Renal Transplant Patients
- Growth Promotion of Mycelia of the Matsutake Mushroom Tricholoma matsutake by D-Isoleucine
- Smad4 is Essential for Down-regulation of E-cadherin Induced by TGF-βin Pancreatic Cancer Cell Line PANC-1
- Blockade of the Dioxin Pathway by Herbal Medicine Formula Bupleuri Minor : Identification of Active Entities for Suppression of AhR Activation(Molecular and Cell Biology)
- Fractionation and Anti-tumor Activity of the Mycelia of Liquid-cultured Phellinus linteus
- Analysis of mitochondrial DNA restriction fragment length polymorphisms for examining genetic variability among isolates of Phellinus linteus
- Usefulness of laparoscopy to find the distal vas deferens during vasovasostomy for a patient with iatrogenic injury of the vas deferens during inguinal herniorrhaphy
- Cadmium nephrotoxicity and evacuation from the body in a rat modeled subchronic intoxication
- Cadmium-induced testicular damage in a rat model of subchronic intoxication
- Body mass index for chronic hemodialysis patients : Stable hemodialysis and mortality
- Surgical treatment for an idiopathic renal arteriovenous fistula with a large aneurysm
- Clinical Experience of Laparoscopic Varicocelectomy in 124 Cases
- Metastatic malignant ameloblastoma of the kidneys
- Comparison of Gas-less laparoscopy-assisted surgery, hand-assisted laparoscopic surgery and pure laparoscopic surgery for radical nephrectomy
- Kidney autotransplantation in a patient with renal pelvic and bladder carcinomas
- Prostate cancer with multiple lung metastases in a hemodialysis patient
- Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis
- Glomerular expression of connexin 40 and connexin 43 in rat experimental glomerulonephritis