Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses
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概要
- 論文の詳細を見る
Kjellmaniella crassifolia Miyabe (gagome) is a brown alga. Oral gagome administration (oral gagome) resulted in significant upregulation of IL-10 and IFNγ production by Peyer’s patch cells. To assess the adjuvant activity of oral gagome, treated mice were subcutaneously injected with ovalbumin (OVA). The production of cytokines from antigen (Ag)-specific T cells in draining lymph nodes (dLN) and their proliferative response were significantly increased as compared with the control group. These enhancements were associated with increased CD44hiCD62L− activated/memory T cells in dLN as well as upregulation of Ag-specific IgA level in luminal contents. No upregulation of cytokine production by dLN T cells was observed in dectin-1-deficient mice, suggesting that the effect of gagome on cytokine production is largely dependent on the dectin-1 pathway despite its composite constituents. Our findings indicate that gagome is an effective immunomodulator and a potent adjuvant for both the intestinal and the systemic immune response.
著者
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Sugi Masahito
Hokkaido Research Institute, Nissei Bio Co., Ltd.
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Adachi Yoshiyuki
Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Iwakura Yoichiro
Center For Experimental Medicine And Systems Biology Institute Of Medical Science University Of Toky
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YAN Huimin
Molecular Composite Medicine Research Group, Biomedical Research Institute, National Institute of Ad
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KAKUTA Shigeru
Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The Universi
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NISHIHARA Masao
Hokkaido Research Institute, Nissei Bio Co., Ltd.
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TSUJI Noriko
Molecular Composite Medicine Research Group, Biomedical Research Institute, National Institute of Ad
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