Presence of A Higher Molecular Weight β-1, 4-Galactosyltransferase in Mouse Liver

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概要

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• Histochemical analyses of β-1, 4-galactosyl-transferase(β-1, 4-GalT)I-knockout mouse liver using anti-bovine β-1, 4-GalT I antibody and Ricinus communis agglutinin(RCA)-I which interacts with oligosaccharides terminated with β-1, 4-linked galactose revealed that weak fluorescence derived from the lectin is present in the mutant mouse in contrast to the disappearance of the immunofluorescence. Lectin blot analysis of membrane glycoproteins showed that many protein bands react with RCA-I although their reactivities are weak in the mutant mouse liver. Upon pretreatment of blots with β-1, 4-galactosidase or N-glycanase, no lectin binding was observed, indicating that a part of N-linked oligosaccharides of β-1, 4-GalT I-knockout mouse liver is galactosylated by yet unidentified β-1, 4-GalT. Gel filtration column chromatography of solubilized mouse liver transferases revealed that β-1, 4-GalT activities in wild-type mouse are detected in fractions 42 and 50 while those in the mutant mouse are detected only in fraction 42. The results indicate that mouse liver contains a high molecular weight β-1, 4-GalT(110K)in addition to a previously known β-1, 4-GalT(46 K).

• 日本組織細胞化学会の論文

著者

• MIKI Kazumasa

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• FURUKAWA Kiyoshi

  Department of Aquatic Biosciences, Graduate School of Agricultural and Life Sciences, The University

• IWAKURA Yoichiro

  Center for Experimental Medicine, Institute of Medical Science, University of Tokyo

• Inoue Manami

  愛知県がんセンター

• Inoue M

  Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute

• Asano Masahide

  Center For Experimental Medicine Institute Of Medical Science University Of Tokyo

• Miki Kazumasa

  First Department Of Inteanal Medicine Faculty Of Medicine Toho University

• Kido Masahiro

  Department Of Gastroenterology And Hepatology Kansai Medical University

• Kido Masahiro

  Department Of Biosignal Research Tokyo Metropolitan Institute Of Gerontology:department Of Gastroent

• Ichinose Masao

  Department Of Gastroenterology Faculty Of Medicine University Of Tokyo

• Ichinose Masao

  Department Of Chemistry Faculty Of Science Tokai University

• Iwakura Yoichiro

  Laboratory Animal Research Center And The Core Research For Evolutional Science And Technology Progr

• Kido Mizuho

  Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science

• Kido Mizuho

  Laboratory Of Oral Anatomy And Cell Biology Graduate School Of Dental Science Kyushu University

• Furukawa Kiyoshi

  Department Of Aquatic Bioscience Graduate School Of Agricultural And Life Sciences The University Of

• Furukawa K

  Department Of Biosignal Research Tokyo Metropolitan Institute Of Gerontology

• Iwakura Y

  Laboratory Animal Research Center And The Core Research For Evolutional Science And Technology Progr

• Iwakura Yoichiro

  Center For Experimental Medicine And Systems Biology Institute Of Medical Science University Of Toky

• Miki Kazumasa

  三菱診療所 内視鏡検査部

• Iwakura Yoichiro

  Center For Experimental Medicine And Systems Biology Inst. Of Medical Sci. The Univ. Of Tokyo

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