Development-Dependent Expression of Cathepsins D and E in Various Rat Tissues, with Special Reference to the High Expression of Cathepsin E in Fetal Liver
スポンサーリンク
概要
- 論文の詳細を見る
The levels of cathepsins D and E in various rat tissues during development were determined with the sensitive assay method we have developed. The level of cathepsin D increased gradually in each tissue during fetal development suggesting the gradual maturation of the lysosomal system in a cell. The level of cathepsin E differed significantly between tissues at various developmental stages. The level in liver increased rapidly from 13-day-gestation fetal stage and decreased gradually at later fetal stages. The level in other tissues such as stomach and spleen began to increase at later fetal stages or the infant stage. Cathepsin E was found in fetal hepatocytes and its gene was hypomethylated when the expression of the gene was elevated. The enzyme was found to be present mainly as a proform suggesting that, after working, an active form is rapidly inactivated.
- 社団法人日本動物学会の論文
著者
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YAHAGI NAOHISA
Endoscopy Unit, Mitsubishi Clinic
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MORIYAMA Akihiko
Division of Biomolecular Science, Institute of Natural Sciences, Nagoya City University
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ICHINOSE Masao
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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MIKI Kazumasa
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Inoue M
Divisions Of Epidemiology & Prevention Aichi Cancer Center Research Institute
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Miki K
Division Of Gastroenterology And Hepatology Department Of Internal Medicine (ohmori) School Of Medic
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Inoue M
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
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Kusakabe Moriaki
Division Of Gastroenterology And Hepatology Department Of Internal Medicine (ohmori) School Of Medic
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Miki Kazumasa
First Department Of Inteanal Medicine Faculty Of Medicine Toho University
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Yahagi Naohisa
Endoscopy Unit Mitsubishi Clinic
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Ichinose Masao
東京大学 医学系研究科消化器内科学
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Ichinose Masao
2nd Department Of Internal Medicine Wakayama Medical University
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Takahashi K
School Of Life Sciences Tokyo Univ. Of Pharmacy And Life Sciences
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KAGEYAMA Takashi
Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University
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YONEZAWA Satoshi
Department of Materials Processing, Tohoku University
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Takaoka Masaya
Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.
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Kusakabe Moriaki
Laboratory Of Cell Biology Tsukuba Life Science Center Riken
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Ichinose M
Laboratory Of Pathology Aichi Cancer Center Research Institute
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YAHAGI Naohisa
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Kojima M
Division Of Gastroenterology And Hepatology Department Of Internal Medicine (ohmori) School Of Medic
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Tatematsu Masae
First Department of Pathology, Aichi Cancer Center Rsearch Institute
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Yonezawa Satoshi
Institute for Developmental Research, Aichi Human Service Center
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Yahagi Naohisa
Department Of Gastroenterology Faculty Of Medicine The University Of Tokyo
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Moriyama Akihiko
Division Of Biomolecular Science Institute Of Natural Sciences Nagoya City University
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Moriyama Akihiko
Department Of Life Science Institute Of Natural Sciences Nagoya City University
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Yoshizaki N
Department Of Animal Resource Production United Graduate School Of Agricultural Science Gifu Univers
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Moriyama A
Nagoya City Univ. Aichi Jpn
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Yonezawa S
Institute For Developmental Research Aichi Human Service Center
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Yonezawa Satoshi
Department Of Embryology Institute For Development Research Aichi Human Service Center
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Takahashi Kyoko
Department Of Food Science And Nutrition School Of Human Environmental Sciences Mukogawa Women'
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Makita Takashi
Dept. Vet. Anat. Yamaguchi Univ.
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Takahashi Kenji
Laboratory Of Molecular Biochemistry School Of Life Science Tokyo University Of Pharmacy And Life Sc
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