Crystal structure of glutamine amidotransferase from Pyrococcus horikoshii OT3
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概要
- 論文の詳細を見る
Glutamine amidotransferases (GATases) hydrolyze glutamine and generate ammonia. The glutamine amide nitrogen is utilized for the biosynthesis of a variety of molecules such as amino acids, coenzymes, antibiotics, purine and pyrimidine nucleotides, and glucosamine. Here, we determined the crystal structure of a GATase (PH1346) from the hyperthermophilic archaeon Pyrococcus horikoshii OT3 at 1.89 Å resolution. Its overall structure and active site are the most similar to those of E. coli guanosine 5-monophosphate (GMP) synthase and Sulfolobus solfataricus anthranilate synthase, respectively. (Communicated by Masanori OTSUKA, M.J.A.)
- 日本学士院の論文
著者
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Kojima M
Univ. Tokyo Tokyo Jpn
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Kusakabe Moriaki
Division Of Gastroenterology And Hepatology Department Of Internal Medicine (ohmori) School Of Medic
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Tanokura Masaru
Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Kojima M
Division Of Gastroenterology And Hepatology Department Of Internal Medicine (ohmori) School Of Medic
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Kamo Masayuki
Univ. Tokyo Tokyo Jpn
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TANOKURA Masaru
Graduate School of Agricultural and Life Sciences, The University of Tokyo
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