Polaprezinc (Zinc <sc>L</sc>-Carnosine) Is a Potent Inducer of Anti-oxidative Stress Enzyme, Heme Oxygenase (HO)-1 — a New Mechanism of Gastric Mucosal Protection

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概要

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• Heme oxygenase (HO)-1 is implicated in cytoprotection in various organs. We tested a possibility that polaprezinc (PZ), an anti-ulcer drug, could induce HO-1 in the gastric mucosa. Male 6-week-old Wistar rats were intragastrically administered PZ. Gastric expression of HO-1 was assessed by real time RT-PCR and western blotting, and localization of HO-1 was observed by in situ hybridization and immunohistochemistry. The levels of HO-1 mRNA were increased in a dose-dependent manner. The levels of HO-1 mRNA were increased 4-fold by PZ at the dose of 200 mg/kg at 3 h as compared with control levels. The levels of immunoreactive HO-1 were increased 3-fold at 6 h. Signals for HO-1 mRNA and immunoreactivity were detected strongly in the surface gastric mucosal cells and moderately in the gastric macrophages. Treatment with an HO-1 inhibitor, stannous mesoporphyrin (SnMP) significantly worsened the HCl-induced acute gastric mucosal lesions and increased the apoptosis of mucosal cells. Mucosal lesions were decreased by pretreatment with PZ, while they were increased by co-administration with SnMP. These data indicate for the first time that PZ is an effective inducer of HO-1 in the stomach. PZ-induced HO-1 functions as a part of the mucosal protective effects of PZ.

著者

• ITO Takao

  Department of Psychiatry, Imaise Branch, Ichinomiya City Hospital

• UEYAMA Takashi

  Departments of Anatomy and Cell Biology, Wakayama Medical University

• Ueyama Takashi

  Department Of Anatomy And Cell Biology Wakayama Medical University

• Ueyama T

  Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

• Ichinose Masao

  2nd Department Of Internal Medicine Wakayama Medical University

• Tsuruo Yoshihiro

  Department of Anatomy and Cell Biology, Wakayama Medical University

• Ueyama Takashi

  Department Of Anatomy And Cell Biology Wakayama Medical University School Of Medicine

• UEDA Kazuki

  2nd Department of Internal Medicine, Wakayama Medical University

• OKA Masashi

  2nd Department of Internal Medicine, Wakayama Medical University

• Uehara Takashi

  Department Of Anatomy And Cell Biology Wakayama Medical University

• Oka Masashi

  東京大学 医学系研究科消化器内科学

• Ueda Kazuki

  2nd Department Of Internal Medicine Wakayama Medical University

• Uehara Takashi

  School Of Allied Health Sciences Osaka University Faculty Of Medicine

• Omata Masao

  2nd Department Of Internal Medicine Wakayama Medical University

• Uehara Takashi

  Department Of Anatomy And Cell Biology Wakayama Medical University School Of Medicine

• Oka Masashi

  2nd Department Of Internal Medicine Wakayama Medical University

• Ito Takao

  Department Of Anatomy And Cell Biology Wakayama Medical University

• Tsuruo Yoshihiro

  Department Of Anatomy And Cell Biology Wakayama Medical University

• Ito Takao

  Department of Anatomy and Cell Biology, Wakayama Medical University, Japan

• Oka Masashi

  2nd Department of Internal Medicine, Wakayama Medical University, Japan

• Ichinose Masao

  2nd Department of Internal Medicine, Wakayama Medical University, Japan

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