Distributions of Steroid 5α-Reductase and 17α-Hydroxylase/C17, 20-lyase (P450c17) Immunoreactivities in Rat Gastric Mucosa
スポンサーリンク
概要
- 論文の詳細を見る
We examined the immunohistochemical localization of steroid 5α-reductase type 1 and 17α-hydroxylase/C17, 20-lyase (P450c17) in rat gastric mucosa. Immunoreactivity of 5α-reductase was localized in the chief cells and the mucous neck cells. P450c17 immunoreactivity was localized in the parietal cells. Subcellular localizations of both 5α-reductase and P450c17 were on the membrane of endoplasmic reticulum. P450c17 is a key enzyme of androgen biosynthesis, and 5α-reductase has a high affinity for testosterone and catalyzes the conversion of testosterone to its 5α-reduced metabolite. Thus, it is suggested that there is an androgenic metabolic pathway in rat gastric mucosa.
- 日本組織細胞化学会の論文
著者
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Yamazaki Takeshi
徳島大学 大学院ヘルスバイオサイエンス研究部
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Yamazaki Takeshi
Faculty Of Integrated Arts And Sciences Material And Life Sciences Hiroshima University
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Tsuruo Yoshihiro
Department of Anatomy and Cell Biology, Wakayama Medical University
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Yokoi Hiromichi
Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima
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Kominami Shiro
Faculty of Integrated Arts and Sciences, Material and Life Sciences, Hiroshima University
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Ishimura Kazunori
Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima
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Kominami S
Faculty Of Integrated Art And Science Hiroshima University
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Kominami Shiro
Faculty Of Integrated Arts And Sciences Hiroshima University
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Kominami Shiro
Faculty Of Integrated Arts And Sciences Material And Life Sciences Hiroshima University
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Ishimura K
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
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Ishimura Kazunori
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
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Ishimura Kazunori
Department Of Anatomy And Cell Biology School Of Medicine Tokushima University
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Yamazaki T
Faculty Of Mechanical Engineering Kanagawa University
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Yokoi Hiromichi
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
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Ishimura Kazunori
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
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Yamazaki Takeshi
Faculty Of Integrated Arts And Sciences Hiroshima University
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Tsuruo Yoshihiro
Department Of Anatomy And Cell Biology Wakayama Medical University
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Kominami Shiro
Faculty Of Integrated Art And Science Hiroshima University
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Yokoi H
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
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Tsuruo Y
Department Of Anatomy And Cell Biology Wakayama Medical University
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