Biochemical and Histochemical Studies of the Effects of Cerebral Metabolism-Improving Drugs on NADPH Diaphorase Activity in Mouse Brain.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of cerebral metabolism-improving drugs on NADPH diaphorase activity in the mouse brain were studied, and we found that diaphorase activity in the post-mitochondrial fraction of brain homogenate was enhanced by idebenone in a concentration-dependent manner. Histochemical studies also indicated that diaphorase staining was intensified by idebenone at the same concentration. These results suggest that idebenone may stimulate the production of nitric oxide, probably through its direct action on nitric oxide synthase, thus producing its protective action on neurological disorders due to cerebral hypoxia or ischemia as a consequence of dilating the cerebral blood vessels.
- 公益社団法人 日本薬理学会の論文
著者
-
Kagawa Susumu
Department Of Urology School Of Medicine Faculty Of Pharmaceutical Sciences The University Of Tokush
-
Tamura Masato
Department Of Biochemistry And Molecular Biology Graduate School Of Dental Medicine Hokkaido Univers
-
Morita Kyoji
Department Of Pharmacology Tokushima University School Of Medicine
-
Ishimura Kazunori
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
-
Tsuruo Yoshihiro
Department Of Anatomy And Cell Biology Wakayama Medical University
-
Ishimura Kazunori
Department of Anatomy, Tokushima University School of Medicine
-
Tsuruo Yoshihiro
Department of Anatomy, Tokushima University School of Medicine
関連論文
- Polaprezinc (Zinc L-Carnosine) Is a Potent Inducer of Anti-oxidative Stress Enzyme, Heme Oxygenase (HO)-1 — a New Mechanism of Gastric Mucosal Protection
- Possible identification of third stromal component in extraadrenal paraganglioma : myofibroblast in fibrous band and capsule
- A case of renal metanephric adenoma:Histologic,immunohistochemical and cytogenetic analyses
- Chronic Estrogen Supplementation Following Ovariectomy Improves the Emotional Stress-Induced Cardiovascular Responses by Indirect Action on the Nervous System and by Direct Action on the Heart
- Immunohistochemical application of D2-40 as basal cell marker in evaluating atypical small acinar proliferation of initial routine prostatic needle biopsy materials
- Distributions of Steroid 5α-Reductase and 17α-Hydroxylase/C17, 20-lyase (P450c17) Immunoreactivities in Rat Gastric Mucosa
- TRUE Gene Silencing : Unique Gene Silencing by the tRNA Maturase tRNase ZL under the Direction of Small-guide RNA
- Angiogenesis and Bone Formation
- Prostatic carcinosarcoma: A case report and review of literature
- Invasive micropapillary carcinoma of the urinary bladder : An immunohistochemical study of neoplastic and stromal cells
- Polaprezinc (Zinc L-Carnosine) Is a Potent Inducer of Anti-oxidative Stress Enzyme, Heme Oxygenase (HO)-1 : a New Mechanism of Gastric Mucosal Protection
- Persistent median artery in the hand : A report with a brief review of the literature
- MS2-2 Androgen metabolizing enzymes in the nervous system
- Metastatic Prostate Carcinoma to the Mandible : Report of a case
- Ureteral small cell carcinoma
- ELEVATION OF STEROID 5α-REDUCTASE mRNA LEVELS IN RAT CEREBELLUM BY TOLUENE INHALATION : POSSIBLE RELATION TO GFAP EXPRESSION
- Cytotoxic Effect of Paraquat on Rat C6 Glioma Cells : Evidence for the Possibility of Non-oxidative Damage to the Cells
- Relevance of Heat-Shock Protein 70 Expression as Histological Marker of Paraquat-Induced Damage to Rat Liver Cells
- Immunohistochemical Studies on Paraquat-Induced Damage to Neuronal and Glial Cells in Rat Hippocampus
- Laparoscopic nephroureterectomy for dysplastic kidney in children : an initial experience
- Secondary amyloidosis of the bladder causing macroscopic hematuria
- Painful Dysesthesia, Hypertension and Autonomic Dysfunction in Acute Polyradiculoneuritis: A Case of Guillain-Barre Syndrome with Hypertension?
- Frequency of High Blood Pressure and Hypertension in Guillain-Barre Syndrome
- Geometry of artificial extracellular matrices : BMP-induced ectopic osteogenesis with three geometrically different titanium-webs(15thAnnual Meeting of the Society for Hard Tissue Regenerative Biology,Session 2)
- Pleiotrophin Regulates Bone Morphogenetic Protein (BMP)-Induced Ectopic Osteogenesis
- Lack of association between the incidence of testicular germ cell tumors and Y-chromosome haplogroups in the Japanese population
- Upregulation of Heme Oxygenase-1 in an Animal Model of Takotsubo Cardiomyopathy
- S13-3 Molecular sub-classification of renal cancer and new diagnostic markers
- Functional evaluation of one-stage urethroplasty with parameatal foreskin flaps of hypospadias using uroflowmetry
- Laparoscopic evaluation of impalpable testis : Analysis of a 9-year experience
- Intra-abdominal testis with loop-like epididymis and intra-canalicular vas and vessels
- Improving the results of OUPF technique for hypospadias repair
- A case of complete testicular feminization:Laparoscopic orchiectomy and analysis of androgen receptor gene mutation
- Activation of the Ca^-Activated K^+ Channel via Protein Kinase A-Dependent Phosphorylation in Human Prostatic Smooth Muscle Cells
- Serological Evaluation of Soluble CD44 in Renal Cancer
- Papillary Cystadenocarcinoma of the Prostate
- High-level Expression of the CD44 Variant Sharing Exon v10 in Renal Cancer
- Panning of a Phage VH Library Using Nitrocellulose Membranes : Application to Selection of a Human VH Library
- A-3 Selection of Antibody Fragments using Phage Display Library and Preparation of Recombinant Antibody
- Neovascularization in Experimental Retinal Venous Obstruction in Rabbits
- 2P302 Partition Coefficient of a Local Anesthetic into Model Biomembranes with Cholesterol-induced Domain Structure(40. Membrane structure,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- Relationship Between Local Sweat Response and Cutaneous Blood Flow Response in Chronic Alcoholics With and Without Neourologic Disorders
- Localization of enolase in synaptic plasma membrane as an αγ heterodimer in rat brain
- The neuronal and endothelium-dependent relaxing responses of human corpus cavernosum under physiological oxygen tension last longer than previously expected
- Steroidogenesis and drug metabolism in adrenocortical cells
- Immunolocalization of Androgen Receptor(AR)and Steroid 5 Alpha-Reductase Type II(5 Alpha-Reductase Type II)in Canine Prostate : -Effect of Antiandrogen, Chlormadinone Acetate(CMA)-
- Histopathological and Immunohistochemical Studies of the Effect of Antiandrogen, Chlormadinone Acetate (CMA), on Canine Spontaneous Benign Prostatic Hyperplasia (BPH)
- Leydig Cells Undergoing Apoptosis in the Perinatal Rat Testis
- P-38 Leydig Cells Undergoing Apoptosis in the Perinatal Rat Testis
- Platelet-type Arachidonate 12-Lipoxygenase in Mouse Gastrointestinal Tract
- Immunolocalization of Steroid 5α-Reductase Type 2 in Human Prostate, Seminal Vesicle and Vas Deferens : Light and Electron Microscopic Immunohistochemistry
- IMMUNOCYTOCHEMICAL STUDY ON THE LOCALIZATION OF AROMATASE IN THE OVARY OF GOLDEN HAMSTER, GUINEA PIG AND COW
- IMMUNOCYTOCHEMICAL DEMONSTRATION FOR CALDESMON AND ACTIN IN THE STRIATED AND SMOOTH MUSCLE CELLS AND NON-MUSCULAR CELLS OF VARIOUS ORGANS OF RATS
- IMMUNOCYTOCHEMICAL LOCALIZATION OF AROMATASE IN OVARIES OF SOME RODENTS, COW AND HUMAN
- Immunocytochemical Demonstration of Caldesmon and Actin in the Smooth Muscle Cells and Non-Muscle Cells of Various Organs.
- Immunocytochemical Demonstration of Caldesmon and Actin in Alimentany Tracts.
- Immunocytochemical Demonstration of the Enzymes for Estrogen Biosynthesis (Aromatase and 17β-Hydroxysteroid Dehydrogenase) in Ovaries of Various Animals.
- Localization of Caldesmon and Actin, and Its Functional Properties in the Thyroid Gland; Immunocytochemical Study
- FREEZE-FRACTURE IMAGES OF DISTRIBUTION OF FILIPIN-CHOLESTEROL COMPLEXES IN THE OVIDUCT EPITHELIUM OF MICE
- FREEZE-FRACTURE IMAGES OF DISTRIBUTION OF FILIPIN-CHOLESTEROL COMPLEXES IN SECRETORY CELLS OF THE ANTERIOR PITUITARY AND ADRENAL MEDULLA OF MICE
- Freeze-fracture studies on filipin-sterol complexes in some secretory cells. : (2)adenohypophysis, adrenal medulla and exocrine pancreas.
- Freeze-fracture studies on filipin-sterol complexes in some secretory cells. : (1)thyroid follicle cells
- IA-12 Morphological analysis of Nociceptin-receptor-expressing cell in the brain(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- P-27 Immunocytochemical localization of 5α-reductase type 1 and 17α-hydroxylase/C17, 20-lyase (P450c17) in the rat gastric mucosa
- Membrane Events during Release of Peptide Hormones
- Chromosomal abnormalities of clear cell renal cell carcinoma : Frequent gain of chromosome 7
- Renal cell carcinoma with extensive clear cell change sharing characteristics of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma
- Adult-onset renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusion with smooth muscle stroma and abnormal vessels
- Carcinoid tumor of the renal pelvis : Consideration on the histogenesis
- Effect of Moderately Increased Intrapelvic Pressure on Renal Tissue Pressure and Vasopressin Release in Rabbits
- Larval diapause induction and termination in a phytophagous lady beetle, Epilachna admirabilis Crotch (Coleoptera : Coccinellidae)
- Prognostic significance of Matrix metalloproteinases-2 activation ratio in renal cell carcinoma
- Intracellular galectin-3 inhibits apoptosis in human prostate cancer
- IA-10 Localization of 5α-reductase in the cerebellum(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- MS2-1 Steroid synthesizing enzymes in the olfactory bulb
- SERUM LEVELS OF A TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) IN BLADDER CANCER PATIENTS
- Recurrent bladder adenocarcinoma in an ileal conduit stoma: A case report
- Immunocytochemical localization of aromatase in ovaries
- Immunocytochemical localization of 3β-HSD and ATP synthase in the adrenal cortical cells.
- Hepatocyte growth factor (HGF) can enhance the invasive ability of renal carcinoma
- ANALYSIS OF nm23 GENE EXPRESSIONS IN HUMAN BLADDER AND RENAL CANCERS
- Biosynthesis, Storage and Release of Catecholamine and the Effects of Drugs on these Processes
- Immediate Effect Of Extracorporeal Shock Waves On The Male Genital System : Gross And Microscopic Study
- Lectin Histochemical Study of Squamous Carcinoma in the Head and Neck Region
- Immunocytochemical localization of aromatase in the rat testis
- Host use in relation to food availability and larval development in the specialist herbivore Epilachna admirabilis (Coleoptera : Coccinelidae)
- Prostatic carcinosarcoma: A case report and review of literature
- Laparoscopic nephroureterectomy for dysplastic kidney in children: an initial experience
- Prognostic significance of matrix metalloproteinases-2 activation ratio in renal cell carcinoma
- Intra-abdominal testis with loop-like epididymis and intra-canalicular vas and vessels
- Functional evaluation of one-stage urethroplasty with parameatal foreskin flaps repair of hypospadias using uroflowmetry
- Chromophobe renal cell carcinoma with prominent lymph node metastasis and polysomy of chromosome 21 : poorly differentiated form or "presarcomatoid" form?
- Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate
- Effects of Flavonoid Compounds on the Activity of NADPH Diaphorase Prepared from the Mouse Brain.
- Idebenone Inhibits Catecholamine Secretion through Its Blocking Action on Ca2+ Channels in Cultured Adrenal Chromaffin Cells.
- Inhibitory action of hydralazine on catecholamine-synthesizing enzymes prepared from bovine adrenal medulla.
- Stimulatory action of Ba2+ on catecholamine biosynthesis in cultured bovine adrenal chromaffin cells: possible relation to protein kinase C.
- Influence of reduction of cytoplasmic ATP on catecholamine secretion from intact and digitonin-permeabilized adrenal chromaffin cells.
- Biochemical and Histochemical Studies of the Effects of Cerebral Metabolism-Improving Drugs on NADPH Diaphorase Activity in Mouse Brain.
- Pharmacological study on Ba2+-stimulated catecholamine secretion from cultured bovine adrenal chromaffin cells: Possible relation of Ba2+ action to Ca2+-activated secretory mechanism.