Angiogenesis and Bone Formation
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概要
- 論文の詳細を見る
Vascularization represents a key mechanism involved in bone growth, cartilage production and bone formation, and is crucial during fracture repair in adults. Changes in this process might induce pathologic conditions such as osteoarthritis or ectopic hone formation. Recent studies identified several endogeneous positive or negative regulators involved in angiogenic processes such as matrix remodeling,cell migration and vessel maturation and these factors were identified as growth factors, matrix metalloproteases, cytokines and integrins. suggesting a molecular mechanisms that could explain how endothelial cells invade tissues and form new blood vessels. Most molecules that have angiogenic activity also enhance osteogenesis in animal experimental models. In this review, we briefly summarize the functions of angiogenic factors and their roles in bone formation and discuss possible future therapeutic uses.
- 日本結合組織学会の論文
- 2004-09-25
著者
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田村 正人
Department Of Ophthalmology Hirosaki University School Of Medicine
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TAMURA Masato
Department of Urology, Kochi Red Cross Hospital
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NAKASHIMA Aiko
Department of Radiology, Himi City Hospital
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Nakashima Aiko
Department Of Biochemistry And Molecular Biology Graduate School Of Dental Medicine Hokkaido Univers
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ZHANG Gui
Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido Unive
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Zhang Gui
Department Of Biochemistry And Molecular Biology Graduate School Of Dental Medicine Hokkaido Univers
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Tamura Masato
Department Of Biochemistry And Molecular Biology Graduate School Of Dental Medicine Hokkaido Univers
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Tamura Masato
Department Of Biochemistry And Molecular Biology Graduate School Of Dental Medicine Hokkaido Univers
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