Effects of Flavonoid Compounds on the Activity of NADPH Diaphorase Prepared from the Mouse Brain.
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概要
- 論文の詳細を見る
The effects of flavonoids on NADPH diaphorase activity were studied in vitro, and we found that the enzyme activity was markedly inhibited by quercetin. This inhibitory action was shown to be accompanied by an increase in the apparent K<SUB>m</SUB> value of the enzyme for the cofactor NADPH, with a decrease in the V<SUB>max</SUB>, and an increase in the apparent K<SUB>m</SUB> for the substrate nitro blue tetrazolium, without any significant change in the V<SUB>max</SUB>. These results indicate that quercetin may directly inhibit NADPH diaphorase, thus suggesting the possibility that this compound may be able to inhibit the production of nitric oxide in the brain.
- 公益社団法人 日本薬理学会の論文
著者
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Kagawa Susumu
Department Of Urology School Of Medicine Faculty Of Pharmaceutical Sciences The University Of Tokush
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MORITA Kyoji
Department of Pharmacology, Tokushima University School of Medicine
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Tamura Masato
Department Of Biochemistry And Molecular Biology Graduate School Of Dental Medicine Hokkaido Univers
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Morita Kyoji
Department Of Pharmacology Tokushima University School Of Medicine
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Ishimura Kazunori
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
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Tsuruo Yoshihiro
Department Of Anatomy And Cell Biology Wakayama Medical University
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