Platelet-type Arachidonate 12-Lipoxygenase in Mouse Gastrointestinal Tract
スポンサーリンク
概要
- 論文の詳細を見る
12-Lipoxygenase enzyme oxygenates the position 12 of arachidonic acid, and produces 12S-hydroperoxy-arachidonic acid. When mouse gastrointestinal tract was immunostained with an antiserum against human platelet 12-lipoxygenase and examined by light microscopy, positively-stained cells were found in the epithelium of stomach and small and large intestines. Electron microscopic immunohistochemistry revealed that the positively-stained cells were open-type enteroendocrine cells. The endocrine cells had many granules of heterogeneous sizes. forms and internalstructures. and most of the granules had electron lucent area. 12-Lipoxygenase was localized in the cytoplasm, but not in the nucleus, plasma membranes and other sub cellular organelles. Double immunostaining revealed that all 12-lipoxygenase positive cells contained serotonin. With an antiserum against 12-lipoxygenase isozyme of porcine leukocytes, no positively-stained cells were observed in gastrointestinal epithelium.
- 日本組織細胞化学会の論文
著者
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Ishimura Kazunori
Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima
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NAKAMURA Michihiro
Department of Clinical Immunology, Medical Institute of Bioregulation, Kyushu University
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Nakamura M
Department Of Anatomy And Cell Biology School Of Medicine Tokushima University
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Nakamura Michihiro
Department Of Biochemistry Tokushima University School Of Medicine
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Nakamura Michihiro
Department Of Anatomy And Cell Biology School Of Medicine Tokushima University
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Yamamoto Shozo
Department Of Biochemistry Tokushima University School Of Medicine
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Ishimura K
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
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Ishimura Kazunori
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
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Ishimura Kazunori
Department Of Anatomy And Cell Biology School Of Medicine Tokushima University
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Ishimura Kazunori
Department Of Anatomy And Cell Biology Institute Of Health Biosciences The University Of Tokushima G
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