INHIBITION OF PROSTAGLANDIN SYNTHESIZING ENZYMES BY HAPTOGLOBIN AND PLASMA OF RATS WITH INFLAMMATION
スポンサーリンク
概要
- 論文の詳細を見る
Administration of carrageenin or adjuvant to rats to induce inflammation produced increases in the plasma haptoglobin level. Simultaneously, there was an increase in the activity of the plasma inhibitor of prostaglandin E<SUB>2</SUB> synthesis. Partially purified haptoglobin inhibited the microsomal over-all conversion of arachidonic acid to prostaglandin E<SUB>2</SUB>. The addition of the haptoglobin inhibited two heme-dependent reactions catalyzed by a purified enzyme of seminal vesicle microsome, <I>i.e.</I>, the prostaglandin G<SUB>2</SUB> synthesis from arachidonic acid and the conversion of prostaglandin G<SUB>2</SUB> to H<SUB>2</SUB>. However, the plasma inhibitory activity was accounted for only partially by the haptoglobin contained in the plasma from treated rats.
- 社団法人 日本薬理学会の論文
著者
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Hashimoto Yoshinobu
Teijin Institute For Biomedical Research
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OHTSU AKIRA
Teijin Institute for Biomedical Research
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HOSHINA KENJI
Teijin Institute for Biomedical Research
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KUROZUMI SEIZI
Teijin Institute for Biomedical Research
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Mizuno Keiko
Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University
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Naruchi Tatsuyuki
Teijin Institute For Bio-medical Research
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Yamamoto Shozo
Department Of Biochemistry Tokushima University School Of Medicine
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KOMORIYA Keiji
Teijin Institute for Biomedical Research, Hino, Tokyo 191
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SAITO Noriyuki
Teijin Institute for Biomedical Research, Hino, Tokyo 191
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KOMORIYA Keiji
Teijin Institute for Biomedical Research
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KUROZUMI Seizi
Teijin Institute for Biomedical Research, Hino, Tokyo 191
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MIZUNO Keiko
Department of Biochemistry, Tokushima University, School of Medicine
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HASHIMOTO Yoshinobu
Teijin Institute for Bio-Medical Research
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HASHIMOTO Yoshinobu
Teijin Institute for Biomedical Research, Hino, Tokyo 191
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Yamamoto Shozo
Department of Biochemistry, Tokushima University, School of Medicine
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HOSHINA Kenji
Teijin Institute for Biomedical Research, Hino, Tokyo 191
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KOMORIYA Keiji
Teijin Institute for Bio-Medical Research
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NARUCHI Tatsuyuki
Teijin Institute for Biomedical Research, Hino, Tokyo 191
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