An experimental model of nephritis induced by calf serum injection in mice.
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概要
- 論文の詳細を見る
Acute glomerulonephritis characterized by proteinuria, hypoalbuminemia and leukocytosis was induced in mice by repeated intraperitoneal injections of calf serum (1 ml/mouse×10). In mice treated with calf serum, hypercellularity, karyorrhexis, expansion of the mesangium and hyalinosis in the glomeruli were observed by light microscopy. Furthermore, circulating immune complexes were detected in the serum, and deposits of mouse IgG and C3 on the basement membranes of the glomeruli were demonstrated immunohistochemically. Oral administration of cyclophosphamide or 6-mercaptopurine at a dose of 20 mg/kg/day significantly suppressed the development of this nephritis. Dexamethasone (0.5 mg/kg/day) caused moderate inhibition of the nephritic changes. These results suggest that this experimental model may be useful for evaluation of anti-nephritic drugs.
- 公益社団法人 日本薬理学会の論文
著者
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HOSODA Kenji
Teijin Institute for Bio-medical Research
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Naruchi Tatsuyuki
Teijin Institute For Bio-medical Research
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Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
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KOYAMA Tamotsu
Teijin Institute for Bio-Medical Research
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Matsuura Eiji
Department Of Cell Chemistry Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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KOMORIYA Keiji
Teijin Institute for Bio-Medical Research
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TAKESHITA Toru
Teijin Institute for Bio-medical Research
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TSUCHIMOTO Masahiro
Teijin Institute for Bio-medical Research, Hino
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TSUCHIMOTO Masahiro
Teijin Institute for Bio-Medical Research
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MATSUURA Eiji
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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