Immunomodulatory activity of the newly synthesized compound TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide).
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概要
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The in vitro and in vivo effects of the newly synthesized compound TOK-8801 (N-(2-phenylethyl)-3, 6, 6-trimethyl-5, 6-dihydroimidazo[2, 1-b]thiazole2-carboxamide) on immune responses were investigated in comparison with that of levamisole (LMS). TOK-8801 enhanced the anti-sheep red blood cells (SRBC) plaque forming cells (PFC) response and mitogen-induced proliferative responses in murine splenocytes and thymocytes in vitro at concentrations of 10<SUP>-7</SUP>-10<SUP>-5</SUP> M, while LMS augmented these responses at 10<SUP>-4</SUP>M. The stimulatory effect of TOK-8801 as well as LMS on the antibody production was eliminated by the removal of T cells. TOK-8801 (0.5 mg/kg, p.o.) suppressed the in vivo generation of anti-SRBC PFC in normal mice, but the compound restored the depressed antibody production in restraint-stress mice which was mainly caused by helper T cell defects. From these results, TOK-8801 was shown to have an immunomodulatory activity in the antibody production.
- 公益社団法人 日本薬理学会の論文
著者
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Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
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FUJIWARA Masami
Department of Physics, College of Engineering, Nihon University
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TAKAYANAGI Noriyasu
Medicinal Research Laboratories, Toyo Jozo Co., Ltd.
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SHIBATA Kensuke
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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MATSUNARI Kenji
Research and Development Department, Kumiai Chemical Industry Co., Ltd.
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FUJIWARA Masami
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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