Antiscorbutic Activity of L-Ascorbic Acid 2-Glucoside and Its Availability as a Vitamin C Supplement in Normal Rats and Guinea Pigs
スポンサーリンク
概要
- 論文の詳細を見る
Bioavailability of a newly-synthesized and chemically-stable 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA-2G) as a vitamin C supplement was investigated in rats and guinea pigs. Oral administration of AA-2G to the animals resulted in an increase of serum ascorbic acid (AA) levels. However, in these sera the intact form was not detectable by the high performance liquid chromatography (HPLC) method, indicating its hydrolysis through the process of absorption. After an intravenous injection of AA-2G, the intact form diminished rapidly from the serum, followed by prolonged and marked elevation of serum AA levels. Various tissue homogenates from rats and guinea pigs were examined for their releasing activity of AA from AA-2G. High activity was observed in kidney, small intestine and serum of rats and in small intestine and kidney of guinea pigs. These hydrolytic activities were completely inhibited by castanospermine, a specific α-glucosidase inhibitor, suggesting the participation of α-glucosidase in the in vivo hydrolysis of AA-2G. AA-2G was found to exhibit obvious therapeutic effect in scorbutic guinea pigs by its repeated oral administrations. These results indicate that AA-2G is a readily available source of vitamin C activity in vivo.
- 社団法人日本薬学会の論文
著者
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Muto Norio
Fac. Of Life And Environmental Sci. Prefectural Univ. Of Hiroshima
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YAMAMOTO Itaru
Department of Radiology, Kanazawa Medical University
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Muto N
Okayama Univ. Okayama
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Yamamoto Itaru
Okayama Univ. Okayama Jpn
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Yamamoto I
Okayama Univ. Okayama Jpn
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Tanaka Mari
Department Of Applied Physics School Of Advanced Science And Engineering Waseda University
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Tanaka Mari
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
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SUGA Sadaharu
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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MITOH Yoshihiro
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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MUTO Norio
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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Muto Norio
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
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Suga S
Okayama Univ. Okayama
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Suga Sadaharu
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Muto N
Graduate School Of Comprehensive Scientific Research Program In Biological System Sciences Prefectur
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Mitoh Yoshihiro
Department Of Oral Physiology Okayama University Graduate School Of Medicine Dentistry And Pharmaceu
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Tanaka Mari
Department of Aerospace Engineering, Tokyo Metropolitan Institute of Technology
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