Protease-Catalyzed Monoacylation of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid in Pyridine
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概要
- 論文の詳細を見る
2-O-α-Glucopyranosyl-6-O-octanoyl-L-ascorbic acid was enzymatically synthesized from 2-O-α-D-glucopyranosyl-L-ascorbic acid(AA-2G)and vinyl octanoate with a protease from Bacillus subtilis in pyridine. Furthermore, with various linear saturated fatty acid vinylesters as acyl donors, AA-2G was also converted to their corresponding 6-O-acyl AA-2G in the same manner. The reactivities of transacylation decreased with increasing length of the acyl groups. Thus, short chain acyl groups were transferred to AA-2G by this protease more efficiently than were long chain acyl groups. This enzymatic method is recommended for the synthesis of 6-Acyl-AA-2G with short or medium length chain acyl groups.
- 公益社団法人日本薬学会の論文
- 2001-08-01
著者
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YAMAMOTO Itaru
Department of Radiology, Kanazawa Medical University
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TAI Akihiro
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
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Tai Akihiro
Department Of Immunochemistry Division Of Pharmaceutical Sciences Okayama University Graduate School
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OKAZAKI Shino
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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TSUBOSAKA Noriko
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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Okazaki Shino
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Tsubosaka Noriko
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
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