DEGRADATION OF HISTAMINE IN THE PRESENCE OF ASCORBIC ACID AND Cu^<2+> ION : INVOLVEMENT OF HYDROGEN PEROXIDE
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概要
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In the presence, but not in the absence of Cu^<2+>, ascorbate decomposes histamine in citrate phosphate buffer (pH 6.5) at 37°, but not at 0°. The breakdown is completely inhibited by catalase, but only slightly by superoxide dismutase, and scavengers of OH・like benzoic acid, ethanol or potassium iodide. A^1O_2 scavenger, α-tocopherol also did not show significant effects on the reaction. On the other hand, addition of H_2O_2 to the reaction mixture markedly enhances the rate of histamine breakdown induced by ascorbate or ascorbate-Cu^<2+> systems. However, H_2O_2 alone cannot breakdown histamine even in the presence of Cu^<2+>. Histamine breakdown induced by ascorbate appears to be dependent upon the autooxidation of this vitamine. From these results and the findings reported by Chatterjee et al. that the products of its aerobic oxidation, dehydroascorbic acid and H_2O_2 were ineffective in reacting with histamine in the presence of Cu^<2+>, it is concluded that the combination of H_2O_2 and the intermediate of ascorbate oxidation (monodehydroascorbic acid or other unstable species), both of which are produced during the autooxidation of ascorbate, plays a major role in the histamine transformation by ascorbate-Cu^<2+> system.
- 公益社団法人日本薬学会の論文
著者
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Ohmori Hitoshi
Department of Bioscience and Biotechnology, Graduate School of Natural Science and Technology, Okaya
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Ohmori Hitoshi
Department Of Bioscience And Biotechnology Graduate School Of Natural Science And Technology Okayama
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YAMAMOTO Itaru
Department of Radiology, Kanazawa Medical University
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Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
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Ohmori Hitoshi
Department Of Medicinal Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
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