Production of an Immunosuppressive Polysaccharide, AZ9, in the Culture of Klebsiella oxytoca Strain TNM3

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概要

• 論文の詳細を見る

• A soil bacterium, Klebsiella oxytoca TNM3, was found to produce a polysaccharide named AZ9 with immunosuppressive activities. The culture of K.oxytoca in a jar fermentor resulted in an extreme increase in the viscosity of the culture broth (>10, 000 mPa・s) due to accumulation of the polysaccharide with a high molecular weight. The molecular weight of AZ9 was successfully controlled by supplementing ethylenediamine tetraacetic acid (EDTA) and Fe^<2+> ion to the culture. Under optimized culture conditions, 39g/l AZ9 with an average molecular weight of 200 kDa was produced, which was effective in suppressing IgE antibody production in mice.

• 社団法人日本生物工学会の論文
• 2001-11-25

著者

• Ohmori Hitoshi

  Department of Bioscience and Biotechnology, Graduate School of Natural Science and Technology, Okaya

• Ohmori Hitoshi

  Department Of Bioscience And Biotechnology Graduate School Of Natural Science And Technology Okayama

• MATSUMOTO Yuki

  Department of Clinical and Laboratory Medicine, Yamanashi Medical College

• SUGIHARA RYOSUKE

  Tayca Corporation

• OISO YOICHI

  Tayca Corporation

• Matsumoto Y

  Department Of Biotechnology Faculty Of Engineering Okayama University

• Matsumoto Yuki

  Department Of Applied Science Tokai University

• Sugihara R

  Tayca Corporation

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