Augmentation of in vitro antibody response by disulfide compounds. I. Comparison between intermolecular and intramolecular disulfides.
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概要
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The following disulfide compounds: 2-hydroxyethyldisulfide (2-ME<SUB>OX</SUB>), 2-aminoethyldisulfide (cystamine) and oxidized dithiothreitol (DTT<SUB>OX</SUB>) were found to augment the in vitro antibody response to sheep erythrocytes in murine lymphocytes as effectively as their reduced forms when they were added to the culture medium. We, however, found out that the mode of action of DTT<SUB>OX</SUB> was greatly different from that of 2-ME<SUB>OX</SUB> or cystamine. 2-ME<SUB>OX</SUB> and cystamine showed augmenting effects on the proliferative response to lipopolysaccharide and on the uptake of (<SUP>35</SUP>S)-cystine by the lymphocytes. In contrast to these intermolecular disulfides, DTT<SUB>OX</SUB>, an intramolecular disulfide compound, was found to be inactive in these systems. 2-ME<SUB>OX</SUB> and cystamine, but not DTT<SUB>OX</SUB>, were reduced to thiol forms by the intact lymphocytes or by the cell homogenate. Thus, it is likely that DTT<SUB>OX</SUB> did not behave as the reduced form in the lymphocyte culture in contrast to 2-ME<SUB>OX</SUB> and cystamine, suggesting that the disulfide form itself plays an important role in augmenting effects of DTT<SUB>OX</SUB>.
- 公益社団法人 日本薬理学会の論文
著者
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Ohmori Hitoshi
Department Of Bioscience And Biotechnology Graduate School Of Natural Science And Technology Okayama
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Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
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Yamauchi Toshihiko
Department Of Electronics Nagoya University
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