Long-Term Radical Scavenging Activity of AA-2G and 6-Acyl-AA-2G against 1,1-Diphenyl-2-picrylhydrazyl
スポンサーリンク
概要
- 論文の詳細を見る
Stoichiometric evaluation of the radical scavenging activity of O-substituted derivatives at the C-2 position of ascorbic acid (AA) was conducted. Their reaction with a stable radical, 1,1-diphenyl-2-picrylhydrazyl (DPPH), under an acidic condition was assessed by the colorimetric method. 2-O-α-_D-Glucopyranosyl-L-ascorbic acid (AA-2G) and a series of 6-O-acyl-2-O-α-_D-glucopyranosyl-_L-ascorbic acids (6-Acyl-AA-2G) had long-term radical scavenging activity against DPPH. The reaction of AA-2G or 6-Acyl-AA-2G with DPPH was very slow when compared with AA. However, one molecule of these derivatives consumed approximately three molecules of DPPH radicals at the end of the experiment (2 h). In contrast, one molecule of AA scavenged two molecules of DPPH radicals, and the reaction ended in the short time (<10 mm). The quantity of radicals quenched by AA-2G and 6-Acyl-AA-2G was superior to that of AA in a long-term reaction.
- 社団法人日本薬学会の論文
- 2002-11-01
著者
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Yamamoto Itaru
岡山大学 薬学部免疫医薬品化学
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YAMAMOTO Itaru
Department of Radiology, Kanazawa Medical University
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Yamamoto I
Okayama Univ. Okayama Jpn
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TAI Akihiro
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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TAKEBAYASHI Jun
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
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Tai A
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Tai Akihiro
Department Of Immunochemistry Division Of Pharmaceutical Sciences Okayama University Graduate School
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Takebayashi Jun
国立健康･栄養研究所 食品機能プロジェクト
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Takebayashi Jun
Food Function And Labeling Program Incorporated Administrative Agency National Institute Of Health A
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Yamamoto I
Department Of Immunochemistry Division Of Pharmaceutical Sciences Okayama University Graduate School
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Takebayashi Jun
Department Of Immunochemistry Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Tai Akihiko
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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