Vitamin C Activity of 2-O-.ALPHA.-D-Glucopyranosyl-L-Ascorbic Acid in Guinea Pigs.
スポンサーリンク
概要
- 論文の詳細を見る
The vitamin C activity of 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA-2G), which is one of chemically stable derivatives of L-ascorbic acid (ASA), in guinea pigs was investigated. Male guinea pigs were divided into 9 groups and fed AsA-deficient diet for 24 days with the following supplement: AA-2G- or AsA-supplemented groups were orally supplemented with 0.96, 1.92, 9.6 and 192 AA-2G mg/animal/day or equimolar amounts of AsA (0.5, 1, 5 and 100mg/animal/day, respectively); AsA-deficient group received neither of them. The body weight gain, serum alkaline phosphatase activity, and the concentration of AsA and AA-2G in the liver, adrenals and urine of the guinea pigs were measured at the end of the experimental period. The AA-2G-supple-mented guinea pigs showed similar body weight gain to the animals sup-plemented with equimolar amount of AsA. Serum alkaline phosphatase activity in both AA-2G- and AsA-supplemented groups was significantly higher than that of AsA-deficient group. But there was no significant difference between the groups supplemented with AA-2G and the equimolar amount of AsA. AA-2G-supplemented guinea pigs showed no apparent symptoms of scurvy. In AA-2G-supplemented groups, AA-2G was not detected in the liver, adrenals and urine, but AsA was found and the AsA concentration increased with increasing AA-2G dosage. The AsA concentration in the tissues of each AA-2G-supplemented groups was higher than that of AsA-deficient group, which was similar to that of the groups supplemented with equimolar amount of AsA. These results showed that AA-2G has the same vitamin C activity as AsA on a molar basis for the orally supplemented guinea pigs.
- 財団法人 学会誌刊行センターの論文
著者
-
Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
-
OTSUKA Megumi
Department fo Nutrition and Food Science, Ochanomizu University
-
Otsuka Megumi
Department of Food and Nutrition, Ochanomizu University
-
ARAKAWA Nobuhiko
Department fo Nutrition and Food Science, Ochanomizu University
-
SUZUKI Emiko
Department of Food and Nutrition, Ochanomizu University
-
AKIBA Masanori
Hayashibara Biochemical Laboratories, Inc.
-
WAKAMIYA Hiroko
Department of Food and Nutrition, Ochanomizu University
関連論文
- Value of whole-body FDG PET in management of lung cancer
- Changes in regional cerebral blood flow in irradiated regions and normal brain after stereotactic radiosurgery
- Single photon emission CT images in a case of intraventricular neurocytoma
- Antiscorbutic Activity of L-Ascorbic Acid 2-Glucoside and Its Availability as a Vitamin C Supplement in Normal Rats and Guinea Pigs
- Formation of a Stable Ascorbic Acid 2-Glucoside by Specific Transglucosylation with Rice Seed α-Glucosidase(Biological Chemistry)
- ACTIVATION OF MURINE LYMPHOCYTES BY 2-MERCAPTOETHANOL AND RELATED THIOL COMPOUNDS AND ITS MECHANISM. II. EFFECT OF THIOL COMPOUNDS ON THE VIABILITY OF THE LYMPHOCYTES UNDER A CYSTINE-DEFICIENT CULTURE CONDITION
- IN VITRO GENERATION OF ANTIGEN-SPECIFIC SUPPRESSOR T CELL ACTIVITY. CULTURE CONDITIONS FOR ABROGATING THE INDUCTION OF NONSPECIFIC SUPPRESSOR T CELLS
- Behavior of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid in a Flour-water Suspension and Its Effectiveness as a Dough Improver
- CT and MRI Findings of Xanthoma in the Orbitofrontal Region
- An isocratic HPLC method for the simultaneous determination of novel stable lipophilic ascorbic acid derivatives and their metabolites
- Characterization of the Radical-Scavenging Reaction of 2-O-Substituted Ascorbic Acid Derivatives, AA-2G, AA-2P, and AA-2S : A Kinetic and Stoichiometric Study(Biopharmacy)
- Inhibition of Hepatocyte Growth Factor Induction in Human Dermal Fibroblasts by Tryptanthrin(Pharmacology)
- pH-Dependent Long-term Radical Scavenging Activity of AA-2G and 6-Octa-AA-2G against 2,2 '-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Radical Cation(Biopharmacy)
- Long-Term Radical Scavenging Activity of AA-2G and 6-Acyl-AA-2G against 1,1-Diphenyl-2-picrylhydrazyl
- Ascorbic Acid 2-O-α-Glucoside-Induced Redox Modulation in Human Keratinocyte Cell Line, SCC : Mechanisms of Photoprotective Effect against Ultraviolet Light B
- Ascorbic Acid 2-O-α-Glucoside, a Stable Form of Ascorbic Acid, Rescues Human Keratinocyte Cell Line, SCC, from Cytotoxicity of Ultraviolet Light B
- Purification and Characterization of a Mouse Hepatocyte Growth-Stimulating Factor from the Liver of Carbon Tetrachloride-Treated Mice
- Inhibition of Hepatocyte Growth Factor Production in Human Fibroblasts by Ursodeoxycholic Acid(Pharmacology)
- Effects of 2,3-Diketo-L-gulonic Acid on the Oxidation of Yolk Lipoprotein
- Vitamin C Activity in Guinea Pigs of 6-O-Acyl-2-O-α-D-glucopyranosyI-L-ascorbic Acids with a Branched-acyl Chain(Food & Nutrition Science)
- Synthesis and Characterization of 6-O-Acyl-2-O-α-D-glucopyranosyl-L-ascorbic Acids with a Branched-acyl Chain
- Bioavailability of a Series of Novel Acylated Ascorbic Acid Derivatives, 6-O-Acyl-2-O-α-D-glucopyranosyl-L-ascorbic Acids, as an Ascorbic Acid Supplement in Rats and Guinea Pigs(Food & Nutrition Sience)
- Radical Scavenging Activity against 1, 1-Diphenyl-2-picrylhydrazyl of Ascorbic Acid 2-Glucoside(AA-2G)and 6-Acyl-AA-2G
- Influence of Cigarette Smoke on the L-Ascorbic Acid Metabolism and the Activities of Drug-Metabolizing Enzyme in Rats
- Physiological Role of L-Ascorbic Acid in Rats Exposed to Cigarette Smoke
- THE USE OF β-CYCLODEXTRIN IN LYMPHOCYTE CULTURE. INDUCTION OF THE PRIMARY ANTIBODY RESPONSE IN VITRO IN CALF SERUM- OR NEWBORN BOVINE SERUM-CONTAINING CULTURE MEDIUM
- ENZYME IMMUNOASSAY OF CYCLIC NUCLEOTIDE
- Activation of Murine Peritoneal Macrophages by Water-Soluble Extracts of Bursaphelenchus xylophilus, a Pine Wood Nematode
- Augmentation by Bursaphelenchus xylophilus, a Pine Wood Nematode, of Polyclonal IgE Production Induced by Lipopolysaccharide Plus Interleukin-4 in Murine Splenocytes
- Gallium-67-citrate scintigraphy of primary renal lymphoma
- Enhancing Effect of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid, a Stable Ascorbic Acid Derivative, on Collagen Synthesis
- DEGRADATION OF HISTAMINE IN THE PRESENCE OF ASCORBIC ACID AND Cu^ ION : INVOLVEMENT OF HYDROGEN PEROXIDE
- Requirement of Cytokines for Augmentation of the Antigen-Specific Antibody Responses by Ascorbate in Cultured Murine T-Cell-Depleted Splenocytes
- Enhancement of Neurite Outgrowth in PC12 Cells Stimulated with Cyclic AMP and NGF by 6-Acylated Ascorbic Acid 2-O-α-Glucosides(6-Acyl-AA-2G),Novel Lipophilic Ascorbate Derivatives
- Synthesis of 2-O-α-D-Glucopyranosyl L-Ascorbic Acid by Cyclomaltodextrin Glucanotransferase from Bacillus stearothermophilus(Biological Chemistry)
- Effects of Rooibos Tea Extract on Antigen-specific Antibody Production and Cytokine Generation in Vitro and in Vivo(Biochemistry & Molecular Biology)
- DEVELOPMENT OF ENZYME IMMUNOASSAY FOR MABUTEROL AND ITS APPLICATION FOR METABOLIC STUDY
- An Increase in Histone Acetylation and IL-2 Antagonizing the Immunoinhibitory Effect Are Necessary for Augmentation by Butyrate of in Vitro Anti-TNP Antibody Production
- In Vitro Augmentation of Natural Killer Activity and Interferon-γ Production in Murine Spleen Cells with Agaricus blazei Fruiting Body Fractions
- Protease-Catalyzed Monoacylation of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid in Pyridine
- Contribution of a High Dose of L-Ascorbic Acid to Carnitine Synthesis in Guinea Pigs Fed High-Fat Diets
- Effects of L-Ascorbic Acid on Lysyl Oxidase in the Formation of Collagen Cross-links(Food & Nutrition Science)
- ACTIVATION OF ALLOPURINOL OXIDIZING ENZYME ACTIVITY OF THE DIALYSATE OF MOUSE LIVER SUPERNATANT BY MONOVALENT CATIONS
- EFFECT OF N-(2-CARBOXYPHENYL)-4-CHLOROANTHRANILIC ACID DISODIUM SALT (CCA) ON THE INDUCTION OF HELPER AND SUPPRESSOR T CELLS IN VITRO AND IN VIVO
- ANTIGEN-INDUCED ELEVATION OF CYCLIC GMP LEVEL IN PLASMA AND ITS ABOLITION IN EXPERIMENTALLY IMMUNOSUPPRESSIVE MICE
- Effects of Thiol Compounds on the Formation of Nitriles from Glucosinolates(Food & Nutrition)
- Effects of pH and Ferrous Ion on the Degradation of Glucosinolates by Myrosinase(Food & Nutrition)
- Time-Dependent Changes of Tissue Erythorbic Acid Concentrations in Guinea Pigs
- The Behavior of _L-Ascorbic Acid in the Prolyl 4-Hydroxylase Reaction(Food & Nutrition)
- The Role of _L-Ascorbic Acid in the Decarboxylation of α-Ketoglutarate Catalyzed by Prolyl 4-Hydroxylase(Food & Nutrition)
- Study on the Volatile Compounds of Fish Sauces : Shottsuru, Nampla and Noucman(Food & Nutrition)
- Scavenging Effects of L-Ascorbic Acid on 1, 1-Diphenyl-2-picrylhydrazyl in Homogeneous and Heterogeneous Reaction Systems
- TISSUE DISTRIBUTION AND CHARACTERISTICS OF XANTHINE OXIDASE AND ALLOPURINOL OXIDIZING ENZYME
- Reduction of Dehydroerythorbic Acid in Vitamin C-Deficient Guinea Pigs
- 2-O-α-D-Glucopyranosyl-L-ascorbic Acid Scavenges 1,1-Diphenyl-2-picrylhydrazyl Radicals via a Covalent Adduct Formation
- Hepatic Branched-Chain α-Keto Acid Dehydrogenase Complex in Female Rats : Activation by Exercise and Starvation
- Histone Hyperacetylation Plays a Role in Augmentation of IL-4-Induced IgE Production in LPS-Stimulated Murine B-Lymphocytes by Sodium Butyrate
- Self-limited septic arthritis caused by Staphylococcus aureus
- Augmentation of Antigen-Specific Antibody Production and IL-10 Generation with a Fraction from Rooibos (Aspalathus linearis) Tea
- In Vitro and In Vivo Prolonged Biological Activities of Novel Vitamin C Derivative, 2-O-α-D-Glucopyranosyl-L-Ascorbic Acid (AA-2G), in Cosmetic Fields
- Evaluation of Urinary Pyridinoline in Healthy Adults and Patients with Rheumatoid Arthritis by an Improved High-performance Liquid Chromatographic Assay
- The Effect of L-Ascorbic Acid on Age-Related Changes of Pyridinoline in Cartilage Collagen of Guinea Pigs
- Contents of Erythorbic Acid in the Tissues of Guinea Pigs Intraperitoneally Administered Erythorbic Acid
- Effect of High Concentration of Ascorbate on Catalase Activity in Cultured Cells and Tissues of Guinea Pigs
- A Positive Correlation between Catalase Activity and Ascorbate Uptake in the Tissues of Guinea Pigs and Cultured Cells of Mammals
- Activities of D and L-Xyloascorbic Acid and D and L-Araboascorbic Acid as a Cofactor for Dopamine β-Hydroxylase Reaction
- Photo-Oxidation of Ethylene with Hydrogen Peroxide
- Augmentation of the antibody response by lipoic acid in mice. I. Analysis of the mode of action in an in vitro culture system.
- Metabolic Fate of Ingested (14C)-Maltitol in Man.
- Role of Hydrogen Peroxide in the Inhibitory Effect of Ascorbate on Cell Growth.
- The Regulatory Effect of Ascorbate on the Carmnitine Synthesis in Primary Cultured Guinea Pig Hepatocytes.
- Age-Related Changes in the Pyridinoline Content of Guinea Pigs Cartilage and Achilles Tendon Collagen.
- An Improved High-Performance Liquid Chromatographic Assay for the Determination of Pyridinoline in Connective Tissues.
- The Behavior of L-Ascorbic Acid in the Healing Process of Dorsal Wounds in Guinea Pigs.
- Comparison of Absorption of Erythorbic Acid and Ascorbic Acid in Guinea Pig Small Intestine.
- Abnormality of the delayed type hypersensitivity (DTH) response to Bordetella pertussis in spontaneously hypertensive rats (SHR).
- An experimental model of nephritis induced by calf serum injection in mice.
- In Situ Intestinal Absorption of 2-0-.ALPHA.-D-Glucopyranosyl-L-Ascorbic Acid in Guinea Pigs.
- Vitamin C Activity of Erythorbic Acid in Ascorbic Acid-Deficient Guinea Pigs.
- Vitamin C Activity of 2-O-.ALPHA.-D-Glucopyranosyl-L-Ascorbic Acid in Guinea Pigs.
- Effect of Fasting on the Endogeneous Inhibitor of Calcium Activated Factor in the Skeletal Muscle of Rats
- Alendronate Modulates Osteogenesis of Human Osteoblastic Cells In Vitro.
- Induction of prolonged elevation of interleukin 2 in the culture medium of murine splenocytes by their precultivation before mitogenic stimulations and its potentiation by glucocorticoid treatment and restraint stress loading.
- Immunomodulatory activity of the newly synthesized compound TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide).
- The use of .BETA.-cyclodextrin-containing culture medium for in vitro evaluation of immunomodulating agents.
- A Rapid and Sensitive Method for the Determination of Ascorbic Acid using 4, 7-Diphenyl-l, 10- phenanthroline
- Augmentation of in vitro antibody response by disulfide compounds. I. Comparison between intermolecular and intramolecular disulfides.
- Some Aspects of the Role of Ascorbic Acid in Proline Hydroxylation
- Isolation and Characterization of an Intermediate Product in the Degradation of 2.3-Diketo-L-gulonic Acid
- Butyrate Enhances the In Vitro Anti-SRBC (Sheep Red Blood Cell) Antibody Responses in Murine Splenocytes.
- Inhibition of proliferative responses and interleukin 2 productions by salazosulfapyridine and its metabolites.
- Enhancement by Ascorbic Acid 2-Glucoside or Repeated Additions of Ascorbate of Mitogen-Induced IgM and IgG Productions by Human Peripheral Blood Lymphocytes.
- Augmentation of the antibody response by lipoic acid in mice. II Restoration of the antibody response in immunosuppressed mice.
- Mutagen Formation after Heating of Mixtures of Guanidino Compounds, Amino Acids and Glucose.
- Effect of Fasting on Calcium Activated Protease in Rat Skeletal Muscle