Augmentation by Bursaphelenchus xylophilus, a Pine Wood Nematode, of Polyclonal IgE Production Induced by Lipopolysaccharide Plus Interleukin-4 in Murine Splenocytes
スポンサーリンク
概要
- 論文の詳細を見る
Bursaphelenchus xylophilus (B. xylophilus) is a pine wood nematode that is known to cause pine wilt disease. We report here that B. xylophilus extracts augmented the polyclonal immunoglobulin E (IgE) production induced by lipopolysaccharide (LPS) plus interleukin-4 (IL-4) both in murine splenocytes and purified B cells as determined by ELISA and ELIspot assays, but they did not cause such a promotion in the absence of either LPS or IL-4. We also observed that the antigen-nonspecific IgE levels were increased in sera of mice treated with B. xylophilus extracts, which were comparable to those of Ascaris suum extracts. These findings suggest that administration of B. xylophilus extracts could suppress allergic diseases via a saturation of mast cell Fcε receptors or/and an inhibition of antigen-specific IgE synthesis to the allergen by a polyclonal response.
- 社団法人 日本薬理学会の論文
- 2003-02-01
著者
-
Kanzaki Hiroshi
Department of Biofunctional Chemistry, Okayama University Graduate School of Natural Science and Tec
-
Yamamoto Itaru
岡山大学 薬学部免疫医薬品化学
-
神崎 浩
岡山大 大学院自然科学研究科(農学系)
-
神崎 浩
岡山大学大学院自然科学研究科バイオサイエンス専攻
-
YAMAMOTO Itaru
Department of Radiology, Kanazawa Medical University
-
TAI Akihiro
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
-
Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
-
Tai A
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
-
Tai Akihiro
Department Of Immunochemistry Division Of Pharmaceutical Sciences Okayama University Graduate School
-
KAJI Hiroaki
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
-
KAWADA Masahiko
Department of Immunochemistry, Faculty of Pharmaceutical Sciences
-
Kaji Hiroaki
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
-
Kaji Hiroaki
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
-
Kawada Masahiko
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences
-
Kanzaki Hiroshi
Department Of Agricultural Chemistry Kyoto University:(present Office)division Of Bio-resources Scie
関連論文
- オリーブ二次代謝産物の微生物変換によって得られる新規抗酸化物質の性状解析
- P-172 ANTIFUNGAL CONSTITUENTS FROM SANTALUM ALBUM OF INDIAN ORIGIN
- 3A11-1 細胞周期阻害剤 dehydrophenylahistin の酵素合成
- 1 脱水素型環状ジペプチド生合成酵素による生理活性物質生産(口頭発表の部)
- C411 糸状菌由来の新規β-N-acetylglucosaminidase阻害剤
- 308 微生物のジケトピペラジン分解酵素
- 生物種の由来が異なる酵素を見分ける阻害剤 : 新規な構造と活性をもつ放線菌由来β-N-アセチルグルコサミニダーゼ阻害剤
- 学産学消の日本酒『おお岡大』
- 岡山大産米100%使用,日本酒「おお岡大」 : 学産学消から学産地消を目指して(大学発!美味しいバイオ)
- 微生物変換による新しい天然由来の化粧品素材開発を目指して--オリーブ葉由来抗酸化成分の微生物による高機能化 (特集 最近の抗老化・抗酸化研究と抗老化剤の開発)
- C209 新規β-N-acetylglucosaminidase阻害剤HU-1の構造解析
- C208 新規β-N-acetylglucosaminidase阻害剤HU-1の阻害特異性
- 昆虫のβ-N-acetylglucosaminidaseに対する阻害剤の探索および部分的性状解析
- 2D15-5 フッ素アミノ酸添加培養による新規フッ素化アルボノルシンの微生物合成(ペプチド工学・プロテオーム,生合成・天然物化学,一般講演)
- 2J13-4 細胞周期阻害剤dehydrophenylahistinのチオカルボニル化(有機化学・高分子化学・生合成・天然物化学,一般講演)
- デヒドロアミノ酸残基を含む生理活性環状ジペプチド類(異常アミノ酸の世界をヘテロな視点で覗く)
- 649 環状ジペプチド分解細菌が生産するジペプチダーゼの精製と諸性質の検討(酵素・酵素工学・タンパク質工学,一般講演)
- 環状ジペプチド脱水素酵素で新規生理活性物質を作る
- 酵素による生理活性物質生産と情報化学の接点
- 国際学会報告 : Bio Trans 2001に参加して
- 微生物由来のジケトピペラジン環化合物代謝酵素による生理活性物質生産
- Enzymatic Conversion of Cyclic Dipeptides to Dehydro Derivatives That Inhibit Cell Division
- 911 環状ジペプチド, cyclo(Gly-Leu)の微生物分解代謝に関与する新規酵素系
- Value of whole-body FDG PET in management of lung cancer
- Changes in regional cerebral blood flow in irradiated regions and normal brain after stereotactic radiosurgery
- Single photon emission CT images in a case of intraventricular neurocytoma
- Antiscorbutic Activity of L-Ascorbic Acid 2-Glucoside and Its Availability as a Vitamin C Supplement in Normal Rats and Guinea Pigs
- Formation of a Stable Ascorbic Acid 2-Glucoside by Specific Transglucosylation with Rice Seed α-Glucosidase(Biological Chemistry)
- ACTIVATION OF MURINE LYMPHOCYTES BY 2-MERCAPTOETHANOL AND RELATED THIOL COMPOUNDS AND ITS MECHANISM. II. EFFECT OF THIOL COMPOUNDS ON THE VIABILITY OF THE LYMPHOCYTES UNDER A CYSTINE-DEFICIENT CULTURE CONDITION
- IN VITRO GENERATION OF ANTIGEN-SPECIFIC SUPPRESSOR T CELL ACTIVITY. CULTURE CONDITIONS FOR ABROGATING THE INDUCTION OF NONSPECIFIC SUPPRESSOR T CELLS
- Behavior of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid in a Flour-water Suspension and Its Effectiveness as a Dough Improver
- CT and MRI Findings of Xanthoma in the Orbitofrontal Region
- An isocratic HPLC method for the simultaneous determination of novel stable lipophilic ascorbic acid derivatives and their metabolites
- Characterization of the Radical-Scavenging Reaction of 2-O-Substituted Ascorbic Acid Derivatives, AA-2G, AA-2P, and AA-2S : A Kinetic and Stoichiometric Study(Biopharmacy)
- Inhibition of Hepatocyte Growth Factor Induction in Human Dermal Fibroblasts by Tryptanthrin(Pharmacology)
- pH-Dependent Long-term Radical Scavenging Activity of AA-2G and 6-Octa-AA-2G against 2,2 '-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Radical Cation(Biopharmacy)
- Long-Term Radical Scavenging Activity of AA-2G and 6-Acyl-AA-2G against 1,1-Diphenyl-2-picrylhydrazyl
- Ascorbic Acid 2-O-α-Glucoside-Induced Redox Modulation in Human Keratinocyte Cell Line, SCC : Mechanisms of Photoprotective Effect against Ultraviolet Light B
- Ascorbic Acid 2-O-α-Glucoside, a Stable Form of Ascorbic Acid, Rescues Human Keratinocyte Cell Line, SCC, from Cytotoxicity of Ultraviolet Light B
- Purification and Characterization of a Mouse Hepatocyte Growth-Stimulating Factor from the Liver of Carbon Tetrachloride-Treated Mice
- 新規の環状ジペプチド脱水素酵素とその活性測定法の確立
- 抗がん活性化合物の酵素合成 (特集 次世代バイオテクノロジーの展開)
- 932 微生物によるcyclo(Gly-Leu)の分解
- Isolation and Characterization of Two Novel Nematicidal Depsipeptides from an Imperfect Fungus, Strain D1084
- Novel Bioactive Oxazolomycin Isomers Produced by Streptomyces albus JA3453
- Inhibition of Hepatocyte Growth Factor Production in Human Fibroblasts by Ursodeoxycholic Acid(Pharmacology)
- Biological and Immunological Properties of Human Hepatocyte Growth Factor from Plasma of Patients with Fulminant Hepatic Failure.
- Vitamin C Activity in Guinea Pigs of 6-O-Acyl-2-O-α-D-glucopyranosyI-L-ascorbic Acids with a Branched-acyl Chain(Food & Nutrition Science)
- Synthesis and Characterization of 6-O-Acyl-2-O-α-D-glucopyranosyl-L-ascorbic Acids with a Branched-acyl Chain
- Bioavailability of a Series of Novel Acylated Ascorbic Acid Derivatives, 6-O-Acyl-2-O-α-D-glucopyranosyl-L-ascorbic Acids, as an Ascorbic Acid Supplement in Rats and Guinea Pigs(Food & Nutrition Sience)
- Radical Scavenging Activity against 1, 1-Diphenyl-2-picrylhydrazyl of Ascorbic Acid 2-Glucoside(AA-2G)and 6-Acyl-AA-2G
- THE USE OF β-CYCLODEXTRIN IN LYMPHOCYTE CULTURE. INDUCTION OF THE PRIMARY ANTIBODY RESPONSE IN VITRO IN CALF SERUM- OR NEWBORN BOVINE SERUM-CONTAINING CULTURE MEDIUM
- Effective Production of Dehydro Cyclic Dipeptide Albonoursin Exhibiting Pronuclear Fusion Inhibitory Activity I. Taxonomy and Fermentation
- Microbial Hydrolysis of Diketopiperazines : Different Types of Diketopiperazine-Assimilating Bacteria
- Inhibitory Effect of Curromycins and Their Esters on Plant Transformation
- An Effective Method of Screening Glucose-rich Microbial Culture Filtrates for Insect Trehalase Inhibitors
- Production of a New Type of Bioactive Phenolic Compound
- ST-1, a Novel Radical Scavenger From Fungus F-124
- ENZYME IMMUNOASSAY OF CYCLIC NUCLEOTIDE
- Activation of Murine Peritoneal Macrophages by Water-Soluble Extracts of Bursaphelenchus xylophilus, a Pine Wood Nematode
- Augmentation by Bursaphelenchus xylophilus, a Pine Wood Nematode, of Polyclonal IgE Production Induced by Lipopolysaccharide Plus Interleukin-4 in Murine Splenocytes
- Gallium-67-citrate scintigraphy of primary renal lymphoma
- Enhancing Effect of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid, a Stable Ascorbic Acid Derivative, on Collagen Synthesis
- Augmentation of Antigen-Specific Antibody Production and IL-10 Generation with a Fraction from Rooibos (Aspalathus linearis) Tea
- DEGRADATION OF HISTAMINE IN THE PRESENCE OF ASCORBIC ACID AND Cu^ ION : INVOLVEMENT OF HYDROGEN PEROXIDE
- Requirement of Cytokines for Augmentation of the Antigen-Specific Antibody Responses by Ascorbate in Cultured Murine T-Cell-Depleted Splenocytes
- Enhancement of Neurite Outgrowth in PC12 Cells Stimulated with Cyclic AMP and NGF by 6-Acylated Ascorbic Acid 2-O-α-Glucosides(6-Acyl-AA-2G),Novel Lipophilic Ascorbate Derivatives
- Synthesis of 2-O-α-D-Glucopyranosyl L-Ascorbic Acid by Cyclomaltodextrin Glucanotransferase from Bacillus stearothermophilus(Biological Chemistry)
- Effects of Rooibos Tea Extract on Antigen-specific Antibody Production and Cytokine Generation in Vitro and in Vivo(Biochemistry & Molecular Biology)
- DEVELOPMENT OF ENZYME IMMUNOASSAY FOR MABUTEROL AND ITS APPLICATION FOR METABOLIC STUDY
- An Increase in Histone Acetylation and IL-2 Antagonizing the Immunoinhibitory Effect Are Necessary for Augmentation by Butyrate of in Vitro Anti-TNP Antibody Production
- In Vitro Augmentation of Natural Killer Activity and Interferon-γ Production in Murine Spleen Cells with Agaricus blazei Fruiting Body Fractions
- Protease-Catalyzed Monoacylation of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid in Pyridine
- Enzymatic Synthesis of Dehydro Cyclo(His-Phe)s, Analogs of the Potent Cell Cycle Inhibitor, Dehydrophenylahistin, and Their Inhibitory Activities toward Cell Division
- あなたはDry派?それともWet派?(若手のページ)
- Relationship between the Pathogenicity of the Pine Wood Nematode, Bursaphelenchus xylophilus, and Phenylacetic Acid Production
- Accumulation of Benzoic Acid in Suspension Cultured Cells of Pinus thunbergii Parl. in Response to Phenylacetic Acid Administration
- ACTIVATION OF ALLOPURINOL OXIDIZING ENZYME ACTIVITY OF THE DIALYSATE OF MOUSE LIVER SUPERNATANT BY MONOVALENT CATIONS
- 2-O-α-D-Glucopyranosyl-L-ascorbic Acid Scavenges 1,1-Diphenyl-2-picrylhydrazyl Radicals via a Covalent Adduct Formation
- Determination of ascorbic acid and its related compounds in foods and beverages by hydrophilic interaction liquid chromatography
- EFFECT OF N-(2-CARBOXYPHENYL)-4-CHLOROANTHRANILIC ACID DISODIUM SALT (CCA) ON THE INDUCTION OF HELPER AND SUPPRESSOR T CELLS IN VITRO AND IN VIVO
- ANTIGEN-INDUCED ELEVATION OF CYCLIC GMP LEVEL IN PLASMA AND ITS ABOLITION IN EXPERIMENTALLY IMMUNOSUPPRESSIVE MICE
- TISSUE DISTRIBUTION AND CHARACTERISTICS OF XANTHINE OXIDASE AND ALLOPURINOL OXIDIZING ENZYME
- Three antinematodal diterpenes from Euphorbia kansui
- 2-O-α-D-Glucopyranosyl-L-ascorbic Acid Scavenges 1,1-Diphenyl-2-picrylhydrazyl Radicals via a Covalent Adduct Formation
- Novel Diketopiperazine Metabolism in a Microorganism : Two-Step Hydrolysis of Cyclo(Gly-Leu)to Amino Acids and Preliminary Characterization of Cyclo(Gly-Leu)Hydrolase and Dipeptidase
- Effective Production of Dehydro Cyclic Dipeptide Albonoursin Exhibiting Pronuclear Fusion Inhibitory Activity : II. Biosynthetic and Bioconversion Studies
- Inhibition of Plant Transformation by Phytolaccoside B from Phytolacca americana Callus
- Improved Bioassay Method for Plant Transformation Inhibitors
- Production of Benzoylformic Acid from Phenylglycine by Saccharomycopsis lipolytica(Microbiology & Fermentation Industry)
- Biosynthetic Intermediates of the Tetradehydro Cyclic Dipeptide Albonoursin Produced by Streptomyces albulus KO-23
- Histone Hyperacetylation Plays a Role in Augmentation of IL-4-Induced IgE Production in LPS-Stimulated Murine B-Lymphocytes by Sodium Butyrate
- Augmentation of Antigen-Specific Antibody Production and IL-10 Generation with a Fraction from Rooibos (Aspalathus linearis) Tea
- In Vitro and In Vivo Prolonged Biological Activities of Novel Vitamin C Derivative, 2-O-α-D-Glucopyranosyl-L-Ascorbic Acid (AA-2G), in Cosmetic Fields
- Augmentation of the antibody response by lipoic acid in mice. I. Analysis of the mode of action in an in vitro culture system.
- Abnormality of the delayed type hypersensitivity (DTH) response to Bordetella pertussis in spontaneously hypertensive rats (SHR).
- An experimental model of nephritis induced by calf serum injection in mice.
- In Situ Intestinal Absorption of 2-0-.ALPHA.-D-Glucopyranosyl-L-Ascorbic Acid in Guinea Pigs.
- Vitamin C Activity of 2-O-.ALPHA.-D-Glucopyranosyl-L-Ascorbic Acid in Guinea Pigs.