Abnormality of the delayed type hypersensitivity (DTH) response to Bordetella pertussis in spontaneously hypertensive rats (SHR).
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概要
- 論文の詳細を見る
The delayed type hypersensitivity (DTH) response of spontaneously hypertensive rats (SHR) was compared with that of Wistar Kyoto rats (WKY), a normotensive strain. SHR showed a lower DTH response to Bordetella pertussis than WKY, especially 48 to 72 hr after antigenic challenge. These results were observed before appearance of abnormality of antibody formation or blood pressure. The reduced DTH responses of SHR were partially restored by either transfer of WKY thymocytes or treatment with levamisole. Conversely, the transfer of SHR thymocytes into WKY rats tended to diminish the DTH response. These findings suggest that SHR have a disfunction of T lymphocytes involved in DTH response (e.g., increase of suppressor cells and/or decrease of helper cells).
- 公益社団法人 日本薬理学会の論文
著者
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OKAMIYA YOSHIAKI
Teijin Institute for Biomedical Research
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Naruchi Tatsuyuki
Teijin Institute For Bio-medical Research
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Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
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KOMORIYA Keiji
Teijin Institute for Bio-Medical Research
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KOMORIYA Keiji
Teijin Institute for Bio-medical Research, Hino
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KUNISAWA Keiko
Teijin Institute for Bio-medical Research
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TAKESHITA Toru
Teijin Institute for Bio-medical Research
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TSUCHIMOTO Masahiro
Teijin Institute for Bio-medical Research, Hino
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KUNISAWA Keiko
Teijin Institute for Bio-medical Research, Hino
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TSUCHIMOTO Masahiro
Teijin Institute for Bio-Medical Research
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TAKESHITA Toru
Teijin Institute for Bio-medical Research, Hino
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OKAMIYA Yoshiaki
Teijin Institute for Bio-medical Research, Hino
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