Augmentation of the antibody response by lipoic acid in mice. II Restoration of the antibody response in immunosuppressed mice.
スポンサーリンク
概要
- 論文の詳細を見る
Lipoic acid (Lip) was examined for its effect on the in vivo antibody response in mice. It was found that Lip significantly restored the suppressed antibody response to sheep erythrocytes (SRBC) in cyclophosphamide-injected mice when it was orally administered at 25 mg/kg twice a day for 4 consecutive days after immunization. On the other hand, Lip-administration did not affect the antibody response in normal mice immunized with SRBC. Normal or cyclophosphamide-treated mice were primed with horse erythrocytes (HRBC) and were given either saline or Lip for 3 consecutive days. HRBC-specific helper T cell activity of their spleen cells were compared by coculturing these cells with trinitrophenyl (TNP)-keyhole limpet hemocyanin-primed spleen cells in the presence of TNP-HRBC as the antigen. A significant restoration of the suppressed helper T cell activity was observed in the Lip-administered group. However, the helper T cell activity was not affected significantly by Lip-administration in normal mice. Lip could also partially restore the helper T cell activities that were suppressed by the treatment with hydrocortisone or X-ray irradiation.
- 公益社団法人 日本薬理学会の論文
著者
-
Ohmori Hitoshi
Department Of Bioscience And Biotechnology Graduate School Of Natural Science And Technology Okayama
-
Yamamoto Itaru
Department Of Immunochemistry Faculty Of Pharmaceutical Science Okayama University
-
Yamauchi Toshihiko
Department Of Electronics Nagoya University
関連論文
- Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line(CELL AND TISSUE ENGINEERING)
- Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation(CELL AND TISSUE ENGINEERING)
- Enhancement of antibody production from a chicken B cell line DT40 by reducing Pax5 expression(MEDICAL BIOTECHNOLOGY)
- Novel In Vitro Screening System for Monoclonal Antibodies Using Hypermutating Chicken B Cell Library(METHOD)
- Impurity Behavior during the H-Mode in JFT-2M
- Ion Bernstein Wave Experiment on JFT-2M Tokamak
- Enhancement of Wall Fueling and Improvement in nτ of a Beam-Heated H-Mode Discharge by Electron Cyclotron Wave in the JFT-2M Tokamak
- Measurement of Peripheral Electron Temperature by Electron Cyclotron Emission during the H-Mode Transition in JFT-2M Tokamak
- Value of whole-body FDG PET in management of lung cancer
- Changes in regional cerebral blood flow in irradiated regions and normal brain after stereotactic radiosurgery
- Single photon emission CT images in a case of intraventricular neurocytoma
- Antiscorbutic Activity of L-Ascorbic Acid 2-Glucoside and Its Availability as a Vitamin C Supplement in Normal Rats and Guinea Pigs
- Formation of a Stable Ascorbic Acid 2-Glucoside by Specific Transglucosylation with Rice Seed α-Glucosidase(Biological Chemistry)
- ACTIVATION OF MURINE LYMPHOCYTES BY 2-MERCAPTOETHANOL AND RELATED THIOL COMPOUNDS AND ITS MECHANISM. II. EFFECT OF THIOL COMPOUNDS ON THE VIABILITY OF THE LYMPHOCYTES UNDER A CYSTINE-DEFICIENT CULTURE CONDITION
- IN VITRO GENERATION OF ANTIGEN-SPECIFIC SUPPRESSOR T CELL ACTIVITY. CULTURE CONDITIONS FOR ABROGATING THE INDUCTION OF NONSPECIFIC SUPPRESSOR T CELLS
- Behavior of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid in a Flour-water Suspension and Its Effectiveness as a Dough Improver
- CT and MRI Findings of Xanthoma in the Orbitofrontal Region
- An isocratic HPLC method for the simultaneous determination of novel stable lipophilic ascorbic acid derivatives and their metabolites
- Characterization of the Radical-Scavenging Reaction of 2-O-Substituted Ascorbic Acid Derivatives, AA-2G, AA-2P, and AA-2S : A Kinetic and Stoichiometric Study(Biopharmacy)
- Inhibition of Hepatocyte Growth Factor Induction in Human Dermal Fibroblasts by Tryptanthrin(Pharmacology)
- pH-Dependent Long-term Radical Scavenging Activity of AA-2G and 6-Octa-AA-2G against 2,2 '-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Radical Cation(Biopharmacy)
- Long-Term Radical Scavenging Activity of AA-2G and 6-Acyl-AA-2G against 1,1-Diphenyl-2-picrylhydrazyl
- Ascorbic Acid 2-O-α-Glucoside-Induced Redox Modulation in Human Keratinocyte Cell Line, SCC : Mechanisms of Photoprotective Effect against Ultraviolet Light B
- Ascorbic Acid 2-O-α-Glucoside, a Stable Form of Ascorbic Acid, Rescues Human Keratinocyte Cell Line, SCC, from Cytotoxicity of Ultraviolet Light B
- Purification and Characterization of a Mouse Hepatocyte Growth-Stimulating Factor from the Liver of Carbon Tetrachloride-Treated Mice
- Inhibition of Hepatocyte Growth Factor Production in Human Fibroblasts by Ursodeoxycholic Acid(Pharmacology)
- Edge Pedestal During the H-Mode of a Tokamak Plasma Measured by the Electron Cyclotron Emission
- Enhancement of Transgene Expression in Mammalian Cell Line by a Δ^7-Prostaglandin A_1 Analogue
- Vitamin C Activity in Guinea Pigs of 6-O-Acyl-2-O-α-D-glucopyranosyI-L-ascorbic Acids with a Branched-acyl Chain(Food & Nutrition Science)
- Synthesis and Characterization of 6-O-Acyl-2-O-α-D-glucopyranosyl-L-ascorbic Acids with a Branched-acyl Chain
- Bioavailability of a Series of Novel Acylated Ascorbic Acid Derivatives, 6-O-Acyl-2-O-α-D-glucopyranosyl-L-ascorbic Acids, as an Ascorbic Acid Supplement in Rats and Guinea Pigs(Food & Nutrition Sience)
- Radical Scavenging Activity against 1, 1-Diphenyl-2-picrylhydrazyl of Ascorbic Acid 2-Glucoside(AA-2G)and 6-Acyl-AA-2G
- High mobility group box-1-inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma
- Development of ICCD Detector for TV Thomson Scattering System on JFT-2M
- Small Bowel Obstruction Caused by Anisakiasis of the Small Intestine : Report of a Case
- Transmesosigmoid Hernia : Report of a Case
- THE USE OF β-CYCLODEXTRIN IN LYMPHOCYTE CULTURE. INDUCTION OF THE PRIMARY ANTIBODY RESPONSE IN VITRO IN CALF SERUM- OR NEWBORN BOVINE SERUM-CONTAINING CULTURE MEDIUM
- ENZYME IMMUNOASSAY OF CYCLIC NUCLEOTIDE
- Activation of Murine Peritoneal Macrophages by Water-Soluble Extracts of Bursaphelenchus xylophilus, a Pine Wood Nematode
- Augmentation by Bursaphelenchus xylophilus, a Pine Wood Nematode, of Polyclonal IgE Production Induced by Lipopolysaccharide Plus Interleukin-4 in Murine Splenocytes
- Gallium-67-citrate scintigraphy of primary renal lymphoma
- Enhancing Effect of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid, a Stable Ascorbic Acid Derivative, on Collagen Synthesis
- DEGRADATION OF HISTAMINE IN THE PRESENCE OF ASCORBIC ACID AND Cu^ ION : INVOLVEMENT OF HYDROGEN PEROXIDE
- Requirement of Cytokines for Augmentation of the Antigen-Specific Antibody Responses by Ascorbate in Cultured Murine T-Cell-Depleted Splenocytes
- Enhancement of Neurite Outgrowth in PC12 Cells Stimulated with Cyclic AMP and NGF by 6-Acylated Ascorbic Acid 2-O-α-Glucosides(6-Acyl-AA-2G),Novel Lipophilic Ascorbate Derivatives
- Synthesis of 2-O-α-D-Glucopyranosyl L-Ascorbic Acid by Cyclomaltodextrin Glucanotransferase from Bacillus stearothermophilus(Biological Chemistry)
- Effects of Rooibos Tea Extract on Antigen-specific Antibody Production and Cytokine Generation in Vitro and in Vivo(Biochemistry & Molecular Biology)
- DEVELOPMENT OF ENZYME IMMUNOASSAY FOR MABUTEROL AND ITS APPLICATION FOR METABOLIC STUDY
- An Increase in Histone Acetylation and IL-2 Antagonizing the Immunoinhibitory Effect Are Necessary for Augmentation by Butyrate of in Vitro Anti-TNP Antibody Production
- In Vitro Augmentation of Natural Killer Activity and Interferon-γ Production in Murine Spleen Cells with Agaricus blazei Fruiting Body Fractions
- Protease-Catalyzed Monoacylation of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid in Pyridine
- Genomic Structures and Chromosomal Location of p91, a Novel Murine Regulatory Receptor Family^1
- Tranilast, an Anti-Allergic Drug, Down-Regulates the Growth of Cultured Neurofibroma Cells Derived from Neurofibromatosis Type 1
- 5-Azacytidine Enhances Transient Expression of a Transfected Gene in Cultured Mammalian Cells
- Enhancement of Expression of the Introduced Gene by 5-Azacytidine in Mammalian Cell Lines
- Methionine-enkephalin secreted by human colorectal cancer cells suppresses T lymphocytes
- Characterization of ASK Mice, a Strain Highly Sensitive to Anaphylactic Shock
- Suppression of in Vitro Cellular Immune Response by Nitrogen-Containing Terpene Alcohol Derivatives
- Enhancement of Expression of Introduced β-Galactosidase Gene by 2-Aminopurine in Mammalian Cell Lines
- ACTIVATION OF ALLOPURINOL OXIDIZING ENZYME ACTIVITY OF THE DIALYSATE OF MOUSE LIVER SUPERNATANT BY MONOVALENT CATIONS
- Measurement of Visible Emission Profiles of JFT-2M Tokamak H-mode Plasmas with Thomson Scattering Apparatus
- EFFECT OF N-(2-CARBOXYPHENYL)-4-CHLOROANTHRANILIC ACID DISODIUM SALT (CCA) ON THE INDUCTION OF HELPER AND SUPPRESSOR T CELLS IN VITRO AND IN VIVO
- Preparation of Al-Pd-Mn Quasicrystal Films by Laser Ablation Method
- ANTIGEN-INDUCED ELEVATION OF CYCLIC GMP LEVEL IN PLASMA AND ITS ABOLITION IN EXPERIMENTALLY IMMUNOSUPPRESSIVE MICE
- TISSUE DISTRIBUTION AND CHARACTERISTICS OF XANTHINE OXIDASE AND ALLOPURINOL OXIDIZING ENZYME
- Production of an Immunosuppressive Polysaccharide, AZ9, in the Culture of Klebsiella oxytoca Strain TNM3
- Search for Immunosuppressive Substances Produced in the Culture of Enteric Bacteria Isolated from Marine Fish
- 2-O-α-D-Glucopyranosyl-L-ascorbic Acid Scavenges 1,1-Diphenyl-2-picrylhydrazyl Radicals via a Covalent Adduct Formation
- Histone Hyperacetylation Plays a Role in Augmentation of IL-4-Induced IgE Production in LPS-Stimulated Murine B-Lymphocytes by Sodium Butyrate
- Subconjunctival Immunization of Mice for Inducing IgE Antibody Response in Parotic Lymph Node
- Plasma Production from a Cesium Adsorbed Layer by a Parallel Laser Beam
- Augmentation of Antigen-Specific Antibody Production and IL-10 Generation with a Fraction from Rooibos (Aspalathus linearis) Tea
- In Vitro and In Vivo Prolonged Biological Activities of Novel Vitamin C Derivative, 2-O-α-D-Glucopyranosyl-L-Ascorbic Acid (AA-2G), in Cosmetic Fields
- Augmentation of the antibody response by lipoic acid in mice. I. Analysis of the mode of action in an in vitro culture system.
- Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet
- Abnormality of the delayed type hypersensitivity (DTH) response to Bordetella pertussis in spontaneously hypertensive rats (SHR).
- An experimental model of nephritis induced by calf serum injection in mice.
- In Situ Intestinal Absorption of 2-0-.ALPHA.-D-Glucopyranosyl-L-Ascorbic Acid in Guinea Pigs.
- Vitamin C Activity of 2-O-.ALPHA.-D-Glucopyranosyl-L-Ascorbic Acid in Guinea Pigs.
- Stress and immune responses. IV. Adrenal involvement in the alteration of antibody responses in restraint-stressed mice.
- Alendronate Modulates Osteogenesis of Human Osteoblastic Cells In Vitro.
- Phorbol Ester-Induced Reversible Inactivation of Cytotoxic T Cell Function: Correlation with Down-Regulation of Protein Kinase C Activity.
- Induction of prolonged elevation of interleukin 2 in the culture medium of murine splenocytes by their precultivation before mitogenic stimulations and its potentiation by glucocorticoid treatment and restraint stress loading.
- Immunomodulatory activity of the newly synthesized compound TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide).
- Demonstration of the Requirements for Cholesterol or Low Density Lipoprotein in the Antibody Response of Murine Lymphocytes in Serum-free Culture
- The use of .BETA.-cyclodextrin-containing culture medium for in vitro evaluation of immunomodulating agents.
- Effects of TGF-.BETA. and TGF-.BETA.-neutralizing Antibody on Normal Skin Fibroblasts and Scar-derived Fibroblasts.
- Augmentation of in vitro antibody response by disulfide compounds. I. Comparison between intermolecular and intramolecular disulfides.
- Stress and immune responses. III. Effect of restraint stress on delayed type hypersensitivity (DTH) response, natural killer (NK) activity and phagocytosis in mice.
- Butyrate Enhances the In Vitro Anti-SRBC (Sheep Red Blood Cell) Antibody Responses in Murine Splenocytes.
- Inhibition of proliferative responses and interleukin 2 productions by salazosulfapyridine and its metabolites.
- Enhancement by Ascorbic Acid 2-Glucoside or Repeated Additions of Ascorbate of Mitogen-Induced IgM and IgG Productions by Human Peripheral Blood Lymphocytes.
- Augmentation of the antibody response by lipoic acid in mice. II Restoration of the antibody response in immunosuppressed mice.