Subconjunctival Immunization of Mice for Inducing IgE Antibody Response in Parotic Lymph Node

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概要

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• Subconjunctival immunization of mice with dinitrophenyl (DNP)-Ascaris plus alum led to the induction of a local anti-DNP IgE response in 8 days. Anti-DNP IgE was found to be secreted from isolated lymphocytes in the parotic lymph node neighboring the immunization site but not from those in the spleen and the mesenteric lymph node. The IgE response was also confirmed by the detection of Cε transcript in the parotic lymph node cells. Ocular topical application of betamethazone resulted in considerable suppression of the IgE response in the parotic lymph node, thus suggesting that this immunization protocol is useful for evaluating ocular topical anti-allergic drugs that are expected to suppress local IgE responses.

• 社団法人 日本薬理学会の論文

著者

• Ohmori Hitoshi

  Department Of Bioscience And Biotechnology Graduate School Of Natural Science And Technology Okayama

• Hikida Masaki

  Department Of Biotechnology Faculty Of Engineering Okayama University

• Okumura Atsushi

  Senju Pharmaceutical Co. Ltd. Chuou-ku

• HARUNA Ken-ichi

  Senju Pharmaceutical Co., Ltd., Chuou-ku

• KISHIMOTO Tatsuya

  Department of Biotechnology, Faculty of Engineering, Okayama University

• Kishimoto Tatsuya

  Department Of Biotechnology Faculty Of Engineering Okayama University

• Haruna Ken-ichi

  Senju Pharmaceutical Co. Ltd. Chuou-ku

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