Search for Immunosuppressive Substances Produced in the Culture of Enteric Bacteria Isolated from Marine Fish

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概要

• 論文の詳細を見る

• Culture supernatants of enteric bacteria isolated from the gastrointestinal tracts of two marine fishes were screened for the production of immunosuppressive substances. At least 50% of the 60 bacterial isolates tested were found to produce immunosuppressants that significantly inhibited the induction of cytotoxic T cells(CTL)in vitro. The strains that secreted the highest suppressive activity was identified as Aeromonas caviae. The immunosuppressive substance purified from the A. caviae culture supernatant was a polysaccharide with a molecular weight of about 70 kDa that contained mannose:glucose(4:1). This polysaccharide did not show nonspecific cytotoxicily, and was found to inhibit the proliferation and differentiation of CD8-positive CTL.

• 社団法人日本生物工学会の論文
• 1998-01-25

著者

• Ohmori Hitoshi

  Department of Bioscience and Biotechnology, Graduate School of Natural Science and Technology, Okaya

• Ohmori Hitoshi

  Department Of Bioscience And Biotechnology Graduate School Of Natural Science And Technology Okayama

• Yazawa Kazunaga

  Sagami Chemical Research Center

• HIKIDA MASAKI

  Department of Biotechnology, Faculty of Engineering Okayama University

• Hikida Masaki

  Department Of Biotechnology Faculty Of Engineering Okayama University

• Oda Toshiyuki

  Department Of Biotechnology Faculty Of Engineering Okayama University

• Oda Toshiyuki

  Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine

• RAITOH MASAYUKI

  Department of Biotechnology, Faculty of Engineering, Okayama University

• HARANO MIKIYA

  Department of Biotechnology, Faculty of Engineering, Okayama University

• SUGIHARA RYOSUKE

  TFT Co.Ltd.

• Harano Mikiya

  Department Of Biotechnology Faculty Of Engineering Okayama University

• Raitoh Masayuki

  Department Of Biotechnology Faculty Of Engineering Okayama University

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