Suppression of in Vitro Cellular Immune Response by Nitrogen-Containing Terpene Alcohol Derivatives

スポンサーリンク

概要

• 論文の詳細を見る

• A series of nitrogen-containing terpene alcohol derivatives were tested for their immunosuppressive effects in vitro, and KYKC-407 (erythro-1-(1-imidazolyl)-3,7,11-trimethyl-dodecane-2(S), 3(R)-diol) was found to be the most effective in suppressing the induction of cytotoxic T cell (CTL) activity. CTL induction in the coculture of C3H spleen cells with mitomycin C-treated BALB/c spleen cells was suppressed by more than 90% when 4 μM KYKC-407 was added to the culture. Under these conditions, lymphocyte proliferation was also suppressed to a similar extent by this compound. Flow cytometric analysis revealed that KYKC-407 strongly inhibited the proliferation of CD8^+ T cell subset, but showed less suppressive effects on CD4^+ T cells. In contrast to cyclosporin A, KYKC-407 at 1-4 μM did not inhibit the proliferative response to concanavalin A. Further, KYKC-407 suppressed CTL induction even in the presence of exogeneous IL-2,thus suggesting that the compound dose not exert its effects through inhibiting IL-2 production.

• 公益社団法人日本薬学会の論文
• 1996-11-15

著者

• Ohmori Hitoshi

  Department of Bioscience and Biotechnology, Graduate School of Natural Science and Technology, Okaya

• Ohmori H

  Riken

• Ohmori H

  Okayama Univ. Okayama Jpn

• Ohmori Hitoshi

  Department Of Bioscience And Biotechnology Graduate School Of Natural Science And Technology Okayama

• Ohmori Hitoshi

  The Institute Of Physical And Chemical Research

• OKADA Yuji

  Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science

• Ohmori H

  Inst. Physical And Chemical Res.(riken) Saitama‐pref. Jpn

• TAKAI TOSHIYUKI

  Department of Biotechnology, Faculty of Engineering Okayama University

• HIKIDA MASAKI

  Department of Biotechnology, Faculty of Engineering Okayama University

• Hikida M

  Okayama Univ. Okayama Jpn

• Hikida Masaki

  Department Of Biotechnology Faculty Of Engineering Okayama University

• MATONO Noriaki

  Department of Biotechnology, Faculty of Engineering, Okayama University

• SHIONO Manzo

  Chemical Research Institute, Kuraray Co., Ltd.,

• Tanigawa Takahiro

  Department Of Biotechnology Faculty Of Engineering Okayama University

• Takai Toshiyuki

  Department Of Biotechnology Faculty Of Engineering Okayama University

• Shiono Manzo

  Chemical Research Institute Kuraray Co. Ltd.

• Matono Noriaki

  Department Of Biotechnology Faculty Of Engineering Okayama University

• Okada Yuji

  Department Of Chemistry Faculty Of Science Saitama University

• OKADA Yuji

  Department of Applied Chemistry, Faculty of Engineering, Osaka University

• OKADA Yuji

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

関連論文

• Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line(CELL AND TISSUE ENGINEERING)
• Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation
• Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation(CELL AND TISSUE ENGINEERING)
• Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line
• Enhancement of antibody production from a chicken B cell line DT40 by reducing Pax5 expression(MEDICAL BIOTECHNOLOGY)
• Novel In Vitro Screening System for Monoclonal Antibodies Using Hypermutating Chicken B Cell Library(METHOD)
• ACTIVATION OF MURINE LYMPHOCYTES BY 2-MERCAPTOETHANOL AND RELATED THIOL COMPOUNDS AND ITS MECHANISM. II. EFFECT OF THIOL COMPOUNDS ON THE VIABILITY OF THE LYMPHOCYTES UNDER A CYSTINE-DEFICIENT CULTURE CONDITION
• IN VITRO GENERATION OF ANTIGEN-SPECIFIC SUPPRESSOR T CELL ACTIVITY. CULTURE CONDITIONS FOR ABROGATING THE INDUCTION OF NONSPECIFIC SUPPRESSOR T CELLS
• Glial Cell Line-Derived Neurotrophic Factor Enhances Nuclear Factor-κB Activity and Invasive Potential in Human Pancreatic Cancer Cells
• Enhanced Angiogenesis Due to Inflammatory Cytokines from Pancreatic Cancer Cell Lines and Relation to Metastatic Potential
• Alteration of Integrin Expression by Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Human Pancreatic Cancer Cells
• Tumor-Forming Pancreatitis Diagnosed Preoperatively as Intraductal Papillary-Mucinous Tumor : Report of a Case
• Alteration of Integrins by Interleukin-1α in Human Pancreatic Cancer Cells
• C30 Grinding Characteristics of Optical Glass for Surface Roughness Reduction(Nano precision Elid-grinding)
• Basic Grinding Characteristics of Ceramic Materials for Dental Crown
• Enhancement of Transgene Expression in Mammalian Cell Line by a Δ^7-Prostaglandin A_1 Analogue
• Development of Aspherical Gradient Index (GRIN) Lens Fabrication System based on VCAD Concept and ELID Grinding(Nanoprecision Elid-grinding (continued))
• ELID Grinding of a Symmetric Paraboloidal Quartz Mirror(Nanoprecision Elid grinding)
• Study on Mirror ELID Grinding of Ceramics and Metals
• High mobility group box-1-inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma
• Small Bowel Obstruction Caused by Anisakiasis of the Small Intestine : Report of a Case
• Transmesosigmoid Hernia : Report of a Case
• Comparison of 30 Immunity-Related Genes from the Common Marmoset with Orthologues from Human and Mouse
• Development of Conductive Rubber-Bond Wheel by ELID Grinding(Nanoprecision Elid grinding)
• THE USE OF β-CYCLODEXTRIN IN LYMPHOCYTE CULTURE. INDUCTION OF THE PRIMARY ANTIBODY RESPONSE IN VITRO IN CALF SERUM- OR NEWBORN BOVINE SERUM-CONTAINING CULTURE MEDIUM
• Development of ELID Honing Method (First Report)
• W1-2 Molecular Mechanisms of Anaphylactic Responses.
• Regulation of murine hypersensitive responses by Fc receptors
• Development of RB Ceramics Bond Diamond Wheel for Eco-friendly ELID Grinding(Nanoprecision Elid grinding)
• Eco-Friendly ELID Grinding Using Metal-Free Electro-Conductive Resinoid Bonded Wheel(Advanced Manufacturing Technology)
• Subsurface Properties of Ceramics for Lightweight Mirrors after ELID Grinding(Advanced Manufacturing Technology)
• Micro V-Groove Grinding Technique of Large Germanium Immersion Grating Element for Mid-Infrared Spectrograph(Advanced Manufacturing Technology)
• DEGRADATION OF HISTAMINE IN THE PRESENCE OF ASCORBIC ACID AND Cu^ ION : INVOLVEMENT OF HYDROGEN PEROXIDE
• Development of Metal - Resin Bonded Wheel Using Fine Metal Powder and Its Grinding Performance
• Characteristics of ELID Surface Grinding by Fine Abrasive Metal-Resin Bonded Wheel
• Study of Precision Machining with Metal Resin Bond Wheel on ELID-lap Grinding
• ELID Mirror Surface Grinding of Hot Die Steel (SKD61) Using Ultra Fine Gift Wheel
• Mirror Surface Grinding of ZrO_2 by Metal Resin Bonded Wheel with ELID
• Expression of Integrins in Intraductal Papillary-Mucinous Tumors of the Pancreas as an Indicator of Malignancy
• Genomic Structures and Chromosomal Location of p91, a Novel Murine Regulatory Receptor Family^1
• Enteritis necroticans 'pigbel' in a Japanese diabetic adult
• 5-Azacytidine Enhances Transient Expression of a Transfected Gene in Cultured Mammalian Cells
• Enhancement of Expression of the Introduced Gene by 5-Azacytidine in Mammalian Cell Lines
• Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses
• Immortalized Dendritic Cell Line with Efficient Cross-Priming Ability Established from Transgenic Mice Harboring the Temperature-Sensitive SV40 Large T-Antigen Gene
• Crystal Structure of the Low-Temperature Phase of x-BaCu_4S_3 Observed by TEM and ED
• Methionine-enkephalin secreted by human colorectal cancer cells suppresses T lymphocytes
• Characterization of ASK Mice, a Strain Highly Sensitive to Anaphylactic Shock
• Suppression of in Vitro Cellular Immune Response by Nitrogen-Containing Terpene Alcohol Derivatives
• Enhancement of Expression of Introduced β-Galactosidase Gene by 2-Aminopurine in Mammalian Cell Lines
• Novel Mast Cell Lines with Enhanced Proliferative and Degranulative Abilities Established from Temperature-Sensitive SV40 Large T Antigen Transgenic Mice
• EFFECT OF N-(2-CARBOXYPHENYL)-4-CHLOROANTHRANILIC ACID DISODIUM SALT (CCA) ON THE INDUCTION OF HELPER AND SUPPRESSOR T CELLS IN VITRO AND IN VIVO
• N, N'-Dicyano-p-acepleiadylenequinonediimine and Its 1,2-Dibromo Derivative : New DCNQI Type Acceptors and Their Conducting Complexes
• Production of an Immunosuppressive Polysaccharide, AZ9, in the Culture of Klebsiella oxytoca Strain TNM3
• Synthesis and Characterization of Some Cationic η^3-Propargylpalladium Complexes
• Serum markers for predicting the severity of acute pancreatitis
• Search for Immunosuppressive Substances Produced in the Culture of Enteric Bacteria Isolated from Marine Fish
• Role of paired Ig-like receptor-B in the humoral immune response
• Variations of magnetic susceptibility and fine quartz accumulation rate in Daisen loam over the past 200 000 years : Interaction between winter and summer monsoons in south-west Japan
• Increased Expression of Angiotensin-converting Enzyme in Retinas of Diabetic Rats
• Finishing Characteristics of ELID-lap Grinding Using Ultra Fine Grain Lapping Wheel
• Subconjunctival Immunization of Mice for Inducing IgE Antibody Response in Parotic Lymph Node
• Peroxiredoxin III-deficiency Sensitizes Macrophages to Oxidative Stress
• Establishment and Functional Characterization of Novel Natural Killer Cell Lines Derived from a Temperature-Sensitive SV40 Large T Antigen Transgenic Mouse
• High Efficiency and Precision Grinding of Ferrite with the Application of ELID (Electrolytic In-Process Dressing)
• Targeting of platelet integrin α_β_3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory FcγR
• The study of allergy by Japanese researchers : a historical perspective
• Augmentation of the antibody response by lipoic acid in mice. I. Analysis of the mode of action in an in vitro culture system.
• Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet
• Induction of a Metallothionein-like Protein in Tetrahymena pyriformis by Metal Ions
• The Isolation and Characterization of a Cadmiumand Zinc-binding Protein from Tetrahymena pyriformis
• Scanning Electron Microscopic and Cytochemical Analyses of Alveolar and Peritoneal Macrophages of Mice, Dogs and Cats.
• Phorbol Ester-Induced Reversible Inactivation of Cytotoxic T Cell Function: Correlation with Down-Regulation of Protein Kinase C Activity.
• Demonstration of the Requirements for Cholesterol or Low Density Lipoprotein in the Antibody Response of Murine Lymphocytes in Serum-free Culture
• The use of .BETA.-cyclodextrin-containing culture medium for in vitro evaluation of immunomodulating agents.
• Augmentation of in vitro antibody response by disulfide compounds. I. Comparison between intermolecular and intramolecular disulfides.
• Augmentation of the antibody response by lipoic acid in mice. II Restoration of the antibody response in immunosuppressed mice.

もっと見る 閉じる

スポンサーリンク