The Effect of Docosahexaenoic Acid on Plasma Catecholamine Concentrations and Glucose Tolerance during Long-Lasting Psychological Stress : A Double-Blind Placebo-Controlled Study

概要

論文の詳細を見る
We previously found that docosahexaenoic acid (DHA) intake prevented aggression from increasing at times of mental stress. In the present study, we investigated whether DHA intake modified the plasma catecholamines and cortisol of medical students during a 9-wk period of final exams. We also investigated the effects of DHA intake on a 75g oral glucose tolerance test (oGTT). Fourteen medical students participated in the present study. They were randomly allocated to either control or DHA group in a double-blind manner. Subjects in the control group (4 males and 3 females) took 10 control capsules/d, each capsule containing 280mg of mixed plant oil, and those in the DHA group (4 males and 3 females) took 10 DHA capsules/d containing 1.5g DHA for 9 wk, during which subjects underwent more than 20 stressful final exams. At the start and end of the study, plasma catecholamines (epinephrine, norepinephrine (NE) and dopamine) and cortisol were measured; a 75g oGTT was also performed. There were no intra- or intergroup differences in plasma glucose concentrations. However, NE concentrations were significantly reduced after DHA administration (-31%, p<0.03). The other catecholamines and cortisol did not change significantly. The plasma ratio of epinephrine to NE increased in every DHA subject (+78%, p<0.02), and intergroup differences were sig-nificant (p<0.03). We conclude that these effects of DHA may be applied to people under long-lasting psychological stress to prevent stress-related diseases.
財団法人学会誌刊行センターの論文
1999-10-01

The Effect of Docosahexaenoic Acid on Plasma Catecholamine Concentrations and Glucose Tolerance during Long-Lasting Psychological Stress : A Double-Blind Placebo-Controlled Study

スポンサーリンク

概要

著者

関連論文

スポンサーリンク