Stimulation of Nerve Growth Factor Synthesis and Secretion by Fellutamide A in Vitro
スポンサーリンク
概要
- 論文の詳細を見る
Fellutamide A, a tripeptide derivative from Penicillium fellutanum was found to be a potent enhancer of nerve growth factor (NGF) synthesis and secretion in vitro. This compound enhanced production of NGF in L-M cells, rat brain cells, and rat glial cells. The mode of action of this compound was suggested to be different from that of a known NGF inducer, epinephrine, as inducing activities of fellutamide A and epinephrine were additive when they were admixed at the concentration which gave saturation in its respective activity. Furthermore, fellutamide A but not epinephrine induced production of NGF in the rat brain cells. NGF-inducing activity of several tripeptides and other compounds related to fellutamide A was examined.
- 社団法人日本農芸化学会の論文
- 1993-02-23
著者
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Shigemori H
Hokkaido Univ. Sapporo Jpn
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Shigemori H
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Yamaguchi K
Kyushu Univ. Fukuoka Jpn
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Yazawa K
Shinshu Univ. School Of Medicine Matsumoto Jpn
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Yazawa Kazunaga
Sagami Chemical Research Center
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Yamaguchi K
Sagami Chemical Res. Center Kanagawa Jpn
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SHIGEMORI Hideyuki
Faculty of Pharmaceutical Sciences, Hokkaido University
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Shigemori Hideyuki
Faculty Of Pharmaceutical Sciences Hokkaido University
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Yamaguchi Kohji
Sagami Chemical Research Center
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TSUJI Tomoko
Sagami Chemical Research Center
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KONDO Kiyosi
Sagami Chemical Research Center
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Kondo K
Laboratory Of Food Biochemistry Nagoya Women's University:(present Address)takemoto Oil & F
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Kobayashi J
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Wakuri Shinobu
Sagami Chemical Research Center
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Yamaguchi Kohji
Tonen Corporation
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Tsuji T
Sagami Chemical Res. Center Kanagawa Jpn
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Kobayashi J
Sapporo Breweries Ltd. Shizuoka Jpn
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