Concanamycin B, a Vacuolar H^+-ATPase Specific Inhibitor Suppresses Bone Resorption in Vitro
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概要
- 論文の詳細を見る
Effects of concanamycin B, a specific inhibitor of the vacuolar type H^+-ATPase (V-ATPase), on the stimulation of bone resorption induced by parathyroid hormone (PTH) were examined in vitro. Concanamycin B was found to inhibit PTH-stimulated osteoclastic pit formation and to suppress the acidification of vacuolar organelles by V-ATPase in the osteoclasts. PTH-stimulated ^<45>Ca release from prelabelled chick embryonic calvariae was also inhibited by concanamycin B in a dose-dependent manner. These results suggest that osteoclastic acidification of lacunae by V-ATPase plays an essential role in mineral dissolution and degradation of the organic matrix during bone resorption.
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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Ohba Yasuo
Department Of Orthodontics School Of Dentistry The University Of Tokushima
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SUMITANI Koji
Department of Orthodontics, School of Dentistry, The University of Tokushima
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Yamaguchi Kohji
Sagami Chemical Research Center
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Woo Je-tae
Dep. Of Biological Chemistry Chubu Univ.
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Woo J‐t
Chubu Univ. Aichi Jpn
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Woo Je-tae
Sagami Chemical Research Center
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Woo Je-tae
Department Of Bioengineering Tokyo Institute Of Technology
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TAGAMI Kahori
Department of Orthodontics, School of Dentistry, The University of Tokushima
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Tagami Kahori
Department Of Orthodontics School Of Dentistry The University Of Tokushima
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Sumitani Koji
Department Of Orthodontics School Of Dentistry The University Of Tokushima
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WOO JeTae
Department of Bioengineering, Tokyo Institute of Technology
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TSUJI Tomoko
Sagami Chemical Research Center
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