Cyclooxygenase Induction Is Essential for NGF Synthesis Enhancement by NGF inducers in L-M Cells
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概要
- 論文の詳細を見る
Nerve growth factor (NGF) inducers, for example, 4-methylcatechol, pyrroloquinoline quinone, kansuinin A, and ingenol triacetate, stimulate NGF synthesis in L-M cells, but the mechanism of NGF induction by NGF inducers is not known. Using the four different types of previously described NGF inducers, we proved induction of cyclooxygenase activity by NGF inducers and detected prostaglandins D_2 and E_2 as metabolites of arachidonic acid. From the observation that the induction of NGF by each NGF inducers was inhibited by cyclooxygenase inhibitors or dexamethasone, cyclooxygenase activation is supposed to be an essential process for NGF induction.
- 社団法人日本農芸化学会の論文
- 1996-01-23
著者
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Yamaguchi K
Kyushu Univ. Fukuoka Jpn
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Yamaguchi K
Sagami Chemical Res. Center Kanagawa Jpn
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Yamaguchi Kohji
Sagami Chemical Research Center
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TSUJI Tomoko
Sagami Chemical Research Center
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KONDO Kiyosi
Sagami Chemical Research Center
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Kondo K
Laboratory Of Food Biochemistry Nagoya Women's University:(present Address)takemoto Oil & F
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Yamaguchi Kohji
Tonen Corporation
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UEMURA Daisuke
Sagami Chemical Research Center
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Tsuji T
Sagami Chemical Res. Center Kanagawa Jpn
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