(2E, 6R)-8-Hydroxy-2,6-dimethyl-2-octenoic Acid, a Novel Anti-osteoporotic Monoterpene, Isolated from Cistanche salsa
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概要
- 論文の詳細を見る
(2E, 6R)-8-Hydroxy-2,6-dimethyl-2-octenoic acid [(R)-HDOA], a novel monoterpene from Cistanche salsa, a Chinese herb, was found to be an anti-osteoporotic compound. The extract of Cistanche salsa significantly suppressed the bone weight loss in ovariectomized mice, a postmenopausal osteoporosis model. The active substance was then purified by using this osteoporotic model and the chemical structure was determined. The active compound from Cistanche salsa, (R)-HDOA, suppressed the decrease of bone weight and the mechanical strength in the ovariectomized mice. Furthermore, (R)-and (S)-HDOA were synthesized and the activity of each was evaluated. (R)-HDOA suppressed the bone weight loss, although (S)-HDOA did not showed any activity.
- 社団法人日本農芸化学会の論文
- 1999-04-23
著者
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Yamaguchi Kohji
Sagami Chemical Research Center
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Sodeoka Mikiko
Sagami Chemical Research Center
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TSUJI Tomoko
Sagami Chemical Research Center
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KOJIMA Sachiko
Sagami Chemical Research Center
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SHINOHARA Chikara
Department of Applied Biological Science, Tokyo Noko University
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SHINOHARA Chikara
Sagami Chemical Research Center
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Shinohara C
Department Of Applied Biological Science Tokyo Noko University
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