Suppressive Effect of Norzoanthamine Hydrochloride on Experimental Osteroporosis in Ovariectomized Mice
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概要
- 論文の詳細を見る
Norzoanthamine is an alkaloid isolated from a colonial zoanthid. We examined the effects of norzanthamine hydrochloride on bone weight, strength and morphology in ovariectomized mice, a postmenopausal osteoporosis model. Norzoanthamine hydrochloride significantly suppressed the decrease in femoral weight and bone biomechanical parameters caused by ovariectomy without an increase in uterine weight. This means that norzoanthamine hydrochloride does not have an estrogen-like effect on reprodcutive organs. Morphological observations of longitudinally ground sections of the humeri showed that norzoanthamine hydrochloride administration (2 mg/kg/d, p.o.) completely suppressed the loss of trabecular bone. Furthermore, norzoanthamine hydrochloride thickened the cortical bone. Based on these results. norzoanthamine hydrochloride may act as both a suppressor of bone resorption and an enhancer of bone formation in vivo.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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UEMURA Daisuke
Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
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Yamaguchi K
Kyushu Univ. Fukuoka Jpn
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Yamaguchi K
Sagami Chemical Res. Center Kanagawa Jpn
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KURAMOTO Makoto
Advanced Instrumentation Center for Chemical Analysis, Ehime University
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Uemura Daisuke
Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University
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Uemura Daisuke
Faculty Of Liberal Arts Shizuoka University
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Yamaguchi Kohji
Sagami Chemical Research Center
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TSUJI Tomoko
Sagami Chemical Research Center
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上村 大輔
名古屋大学大学院理学研究科
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YADA Mika
Sagami Chemical Research Center
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Yamaguchi Kohji
Tonen Corporation
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Tsuji T
Sagami Chemical Res. Center Kanagawa Jpn
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Kuramoto M
Department Of Material Science Integrated Center For Science Ehime University
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Kuramoto Makoto
Advanced Instrumentation Center For Chemical Analysis Ehime University
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