104(P51) 骨粗鬆症抑制作用物質Norzoanthamineの構造活性相関(ポスター発表の部)

概要

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Norzoanthamine (1), is a zoanthamine-type alkaloid isolated from the colonial zoanthid Zoanthus sp. Norzoanthamines inhibit IL-6 production. Furthermore, norzoanthamine hydrochloride, which suppresses the decrease in bone weight and strength in ovariectomized mice, could be a good candidate for an osteoporotic drug. Although the relative configuration of norzoanthamine was established based on an X-ray crystallographic analysis, the absolute conformation of norzoanthamines, including zoanthamines which have been reported previously, remains unclear. To investigate their biogenesis and mechanism of biologocal action, we conducted chemical and spectroscopic studies to determine the absolute configuration of norzoanthamines. We report here the absolute stereochemistry, a proposed biogenesis and bioactivities of norzoanthamines.
天然有機化合物討論会の論文
1997-07-20