80(P-37) 愛媛県産海洋生物由来の細胞毒性物質(ポスター発表の部)

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Ehime Prefecture was surrounded in the sea, and the fishery was popular from a past. Especially, many marine organisms are got around Sada Cape by the effect of the tide. Though in the Misaki town, the fishing using the network is carried out, seaweed and sponge are large obtained with the fish. However, sponge and seaweed without the value as goods are being discarded without utilizing. In our continuing search for biologically active substances from such marine organisms, three furanoterpenes (1, 2, 3) and novel alkaloid (4) were isolated from the marine sponge Ircinia sp. collected at Sada Cape. The methanolic extract of Ircinia sp. was extracted with ethyl acetate. The ethyl acetate extraction showed cytotoxic activity (IC_<50> 0.02 μg/ml) against the murine leukemia cell line P388. The residue was purified by hexane extraction, SiO_2 column chromatography, and HPLC to give cytotoxic compounds (1-4). The structures of these compounds were elucidated mainly by detailed analysis of NMR data and MS spectral data. Some kind of brown alga has also given the damage to other organism in order to put the acid out, when it is injured, while self it discolors to the green. This property seems to be the prey aversion for the predator. Polyhalogenated monoterpenes (5, 6) were isolated from such brown alga Desmarestia ligurata. The structure of 5 was deduced by the detailed comparison with known compounds. Interestingly, the result of the optical rotation estimated that 5 was an enantiomer of known compound. These compound showed weak activity against the murine leukemia cell line P388. We reported here the isolation and structural elucidation of these compounds.
天然有機化合物討論会の論文
2001-09-01

80(P-37) 愛媛県産海洋生物由来の細胞毒性物質(ポスター発表の部)

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