Exploratory research on bioactive natural products with a focus on biological phenomena
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概要
- 論文の詳細を見る
The discovery of new basic compounds holds the key for advancing material sciences. We have focused on the identification and characterization of natural key compounds that control biologically and physiologically intriguing phenomena. The discovery of new bioactive molecules, facilitated by a deeper understanding of nature, should advance our knowledge of biological processes and lead to new strategies to treat disease. The structure and function of natural compounds are sometimes unexpectedly original. Based on our past experience and results, we have carried out research to find new directions for compound exploration by directly learning from dynamic biological phenomena in the field, and have succeeded in creating a new research field in biological molecular sciences.(Communicated by Satoshi OMURA, M.J.A.)
著者
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UEMURA Daisuke
Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
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Uemura Daisuke
Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University
関連論文
- Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells
- Exploratory research on bioactive natural products with a focus on biological phenomena
- P-272 Synthetic Study of Nakiterpiosin
- PALYTOXIN FORMS NEW IONIC CHANNELS
- Development of Chemical Substances Regulating Biofilm Formation
- Tanzawaic Acids A, B, C, and D : Inhibitors of Superoxide Anion Production from Penicillium citrinum
- Preparation of Quinoline Hexose Analogs as Novel Chloroquine-Resistant Malaria Treatments (1). Synthesis of 4-Hydroxyquinoline-β-glucosides
- P-144 BIOORGANIC CHEMICAL STUDIES ON KARATUNGIOLS A-D, NOVEL SUPER-CARBON-CHAIN COMPOUNDS FROM THE SYMBIOTIC MARINE DINOFLAGELLATE AMPHIDINIUM SP.
- P-142 Structure of Symbiodinolide, a Super-carbon-chain Compound Isolated from the Symbiotic Dinoflagellate Symbiodinium sp.
- Synthetic Studies of Norzoanthamine. Preparation of the Diene-yne-diene Precursor of an ABC-ring Fragment
- Isolation of Tribromoacetamide from an Okinawan Alga and Biological Activities of Its Analogs
- Haterumaimides J and K, Potent Cytotoxic Diterpene Alkaloids from the Ascidian Lissoclinum Species
- Kohamaic Acids A and B, Novel Cytotoxic Sesterterpenic Acids, from the Marine Sponge Ircinia sp.
- Isolation and Structures of Attenols A and B. Novel Bicyclic Trials from the Chinese Bivalve Pinna attenuate
- A17 OKADAIC ACID AND CALYCULIN A, TOXINS ISOLATED FROM MARINE SPONGE, INHIBIT PROTEIN PHOSPHATASE ACTIVITY AND CONTRACT SMOOTH MUSCLE
- P-246 SYNTHETIC STUDY OF TERPIODIENE
- Durinskiol B : A New Durinskiol Congener from the Symbiotic Marine Dinoflagellate Durinskia sp.
- Haterumadienone : A New Puupehenone Congener from an Okinawan Marine Sponge, Dysidea sp.
- Dinohydrazides A and B, Novel Hydrazides from a Symbiotic Marine Dinoflagellate
- Papillamide, a Novel Fatty Acid Amide from the Red Alga Laurencia papillosa
- Application of FITC-labeled Ternatin on Its Cellular Localization in 3T3-L1 Murine Preadipocytes
- P-412 CHEMICAL INVESTIGATION ON BIOLOGICAL ACTIVE COMPOUNDS FROM DINOFLAGELLATES
- P-397 Characterization of a Natural Inducer of Coral Larval Metamorphosis
- P-269 (-)-Ternatin, which inhibits fat accumulation against 3T3-L1 adipocytes, from the mushroom Coriolus versicolor
- P-249 FEEDING ATTRACTANTS FOR THE NECKLACE SHELL Neverita dydima, A CLAM PREDATOR
- P-224 STUDIES ON CYTOTOXIC COMPOUNDS FROM RED ALGAE WHICH OVERGROW CORALS
- P-288 Synthetic Study of Symbioimine
- Studies in Bioactive Marine Alkaloids
- Stereostructure and Bioactivities of Jolkinolide D
- Suppressive Effect of Norzoanthamine Hydrochloride on Experimental Osteroporosis in Ovariectomized Mice
- Structure-Activity Relationship of Norzoanthamine Exhibiting Significant Inhibition of Osteoporosis
- P-221 Unified Total Synthesis and Stereochemistry of Pteriatoxins A-C and Pinnatoxins B/C
- Hepatoprotective Effect of a Hot-Water Extract from the Edible Thorny Oyster Spondylus varius on Carbon Tetrachloride-Induced Liver Injury in Mice
- P-99 SOLID-PHASE SYNTHESIS OF DEHYDROPEPTIDES
- Terpiodiene : A Novel Tricyclic Alcohol from the Okinawan Sponge Terpios hoshinota
- Halichlorine Reduces Monocyte Adhesion to Endothelium Through the Suppression of Nuclear Factor-κB Activation
- Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells
- P-53 Studies on the Asymmetric Total Synthesis of Halichlorine and Pinnaic Acid
- Iminium Alkaloids from Marine Invertebrates : Structure, Biological Activity, and Biogenesis
- Melanin Biosynthesis Inhibitors from Tarragon Artemisia dracunculus
- Halichlorine Reduces Monocyte Adhesion to Endothelium Through the Suppression of Nuclear Factor-κB Activation
- Construction of a Metagenomic Library for the Marine Sponge Halichondria okadai
- Isolation and Structure of a Novel Biindole Pigment Substituted with an Ethyl Group from a Metagenomic Library Derived from the Marine Sponge Halichondria okadai
- Isolation of 9-Hydroxy-10E, 12Z-octadecadienoic Acid, an Inhibitor of Fat Accumulation from Valeriana fauriei
- The isolation and structure of toxic principles, milliamines A, B, and C, from Euphorbia Millii.