Pharmacological Topics of Bone Metabolism : Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival

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概要

• 論文の詳細を見る

• The mass and function of bones depends on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Osteoporosis typically reflects an imbalance in skeletal turnover, such that bone resorption exceeds bone formation. Osteoclasts are target cells for anti-osteoporosis therapies. To discover new types of antiresorptive agents, we screened for natural compounds that regulate osteoclast differentiation, function, and survival. As a result, we identified reveromycin A, destruxins, mevastatin, FK506, cyclosporin A, prodigiosins, concanamycins, and symbioimine among microbial natural compounds. In this review, we discuss the mechanisms of action of these compounds on osteoclasts.

• 社団法人 日本薬理学会の論文
• 2008-04-20

著者

• NAGAI Kazuo

  Department of Bioengineering, Tokyo Institute of Technology

• Cha Byung-yoon

  Res. Inst. For Biological Functions Chubu Univ.

• Teruya Toshiaki

  Department of Chemistry, University of Tsukuba

• Nagai Kazuo

  Department Of Applied Biological Chemistry Chubu University

• Nagai Kazuo

  Research Institute for Biological Functions, Chubu University

• WOO Je-Tae

  Department of Bioengineering, Tokyo Institute of Technology

• TERUYA Toshiaki

  Research Institute for Biological Functions, Chubu University

• Woo Je-tae

  Dep. Of Biological Chemistry Chubu Univ.

• Woo J‐t

  Chubu Univ. Aichi Jpn

• Woo Je-tae

  Department Of Applied Biological Science Tokyo Noko University

• Woo Je-tae

  Sagami Chemical Research Center

• Woo Je-tae

  Department Of Bioengineering Tokyo Institute Of Technology

• Teruya Toshiaki

  Res. Inst. For Biological Functions Chubu Univ.

• Teruya Toshiaki

  Department Of Chemistry Faculty Of Science And Technology Keio University

• YONEZAWA Takayuki

  Department of Biological Chemistry, Chubu University

• CHA Byung-Yoon

  Department of Biological Chemistry, Chubu University

• Yonezawa Takayuki

  Research Institute For Biological Functions Chubu University

• Nagai Kazuo

  Department Of Biological Chemistry Chubu University

• Nagai Kazuo

  Research Institute For Biological Functions Chubu University

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